Results 71 to 80 of about 43,837 (307)

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Trimerization of 1,2‐Diaminocyclohexane Catalyzed by a Metal–Organic Cage Tandem Catalyst with Dual Biomimetic Active Sites

Advanced Science, EarlyView.
Dual biomimetic active sites, i.e., mononuclear {ZnII(L)(H2O)} and dinuclear {L2ZnII(CHO2)(OH)ZnIIL2}, have been successfully intergrated into a metal–organic cage, Zn20‐MOC. These two different active sites in Zn20‐MOC catalyze different steps of cascade trimerization of 1,2‐diaminocyclohexane. The mononuclear {ZnII(L)(H2O)} site catalyzes the initial
Xiao‐Jun Chai, Zhu Zhuo, Zi‐Ang Nan, Shiqiang Mu, Zhong‐Yu Peng, Ting Chen, Wei Wang, Li‐Feng Lin, Xi Meng, Mao‐Chun Hong, You‐Gui Huang   +10 more
wiley   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding

Angewandte Chemie, EarlyView.
A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka   +8 more
wiley   +2 more sources

Living Biotherapeutics Using Nanoparticles‐Armed Cyanobacteria for Boosting Photodynamic‐Immunotherapy of Cancer

Advanced Science, EarlyView.
A schematic illustration of the cyanobacteria‐based biohybrid platform for photodynamic cancer therapy enhanced PDT. The platform continuously outputs O2 (to alleviate tumor hypoxia) and 1O2 (for tumor treatment), achieving improved photodynamic immunotherapy. Abstract The interdisciplinary development of synthetic biology and material sciences propels
Zhengwei Xu, Mingsong Zang, Hui Li, Ruizhen Tian, Zherui Zhang, Wang Liu, Fei Xiao, Xuesha Yan, Yan Zhu, Canhong Zhu, Jiayun Xu, Shuangjiang Yu, Tingting Wang, Hongcheng Sun, Junqiu Liu   +14 more
wiley   +1 more source

TaPPR13, a Pentatricopeptide Repeat Protein Gene Activated by TaBZR2, Confers Drought Stress Tolerance by Enhancing the Antioxidant Defense System and Promoting Retrograde Signaling in Wheat (Triticum aestivum)

Advanced Science, EarlyView.
TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou, Wei‐Jun Zheng, Lei Zheng, Jing‐Yue Wang, Shuang‐Xi Zhang, Ji‐Tong Wei, Shu‐Hui Yang, Yuan‐Chen Jiao, Wen‐Jing Cheng, Tai‐Fei Yu, Xiao‐Fei Ma, Jing‐Na Ru, Yong‐Wei Liu, Xin‐You Cao, Jun Chen, Yong‐Bin Zhou, Ming Chen, Li‐Hui Li, You‐Zhi Ma, Xiao‐Jun Nie, Zhao‐Shi Xu   +20 more
wiley   +1 more source

EVALUATING THE EFFECTIVENESS OF CURETTAGE OF PERIODONTAL POCKETS ON CYTOENZIMOCHEMICAL INDICATORS

Кубанский научный медицинский вестник, 2017
The results of the study cytoenzimechemical biologically research of neutrophilic granulocytes For an assessment of efficiency of medical manipulations after curettage of periodontal pockets Average degree weight of inflammatory process.
M. S. GANDZHA, K. S. GANDYLYAN, Y. N. MAYBORODA   +2 more
doaj   +1 more source

Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2002
A comprehensive phylogenetic analysis of the core subunits of succinate:quinone oxidoreductases and quinol:fumarate oxidoreductases is performed, showing that the classification of the enzymes as type A to E based on the type of the membrane anchor fully correlates with the specific characteristics of the two core subunits.
Cláudio M. Gomes, Rita S. Lemos, Andreia S. Fernandes, Manuela M. Pereira, Miguel Teixeira   +4 more
openaire   +3 more sources

Cu7S4 Nanozyme Efficiently Inactivating Drug‐Resistant Bacteria on Mouse Wound Models through Photodynamic and Photothermal Synergetic Therapy

Advanced Science, EarlyView.
Cu7S4 nanozymes, exhibiting peroxidase‐like, catalase‐like, and GSH‐depletion activities, are synthesized through defect engineering. These nanozymes demonstrate rapid inactivation of Gram‐negative bacteria, including Escherichia coli and Pseudomonas aeruginosa. In a mouse skin wound model infected with P. aeruginosa, the nanozyme showcases exceptional
Xueya Li, Dazhen Liu, Song Han, Yujia Liu, Yuanyang Fan, Yu Zhang, Chunchang Li, Zhenshan Xia, Lingbing Cui, Jing Cui, Jinghong Wen, Tao Yan, Chuanjia Jiang, Yongxin Jin, Qian Ren, Mingyang Liu   +15 more
wiley   +1 more source

Dramatic down-regulation of oxidoreductases in human hepatocellular carcinoma hepG2 cells: proteomics and gene ontology unveiling new frontiers in cancer enzymology

Proteome Science, 2008
Background Oxidoreductases are enzymes that catalyze many redox reactions in normal and neoplastic cells. Their actions include catalysis of the transformation of free, neutral oxygen gas into oxygen free radicals, superoxide, hydroperoxide, singlet ...
Ngoka Lambert CM
doaj   +1 more source