Results 81 to 90 of about 44,293 (292)

Dramatic down-regulation of oxidoreductases in human hepatocellular carcinoma hepG2 cells: proteomics and gene ontology unveiling new frontiers in cancer enzymology

open access: yesProteome Science, 2008
Background Oxidoreductases are enzymes that catalyze many redox reactions in normal and neoplastic cells. Their actions include catalysis of the transformation of free, neutral oxygen gas into oxygen free radicals, superoxide, hydroperoxide, singlet ...
Ngoka Lambert CM
doaj   +1 more source

Non‐Random Distribution of EMS‐Induced Mutations Reveals Preference for Open Chromatin and Expressed Genes in Rice

open access: yesAdvanced Science, EarlyView.
Mutagenesis is an effective method for generating genetic resources with a long history in breeding; however, the randomness of chemical‐induced mutations has not been systematically investigated. In this study, over 7 million SNPms are identified in an EMS‐induced population, revealing that these mutations are non‐randomly distributed and ...
Xue‐Feng Yao   +8 more
wiley   +1 more source

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad   +9 more
wiley   +1 more source

Endoplasmic reticulum (ER) Chaperones and Oxidoreductases: Critical Regulators of Tumor Cell Survival and Immunorecognition

open access: yesFrontiers in Oncology, 2014
Endoplasmic reticulum (ER) chaperones and oxidoreductases are abundant enzymes that mediate the production of fully folded secretory and transmembrane proteins. Resisting the Golgi and plasma membrane-directed bulk flow, ER chaperones and oxidoreductases
Thomas eSimmen, Tomas eGutierrez
doaj   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang   +9 more
wiley   +1 more source

Soil Extracellular Enzymes from Brazilian Cerrado as Quality Bioindicators in Agricultural Areas in Goiás, Brazil

open access: yesFronteiras: Journal of Social, Technological and Environmental Science, 2016
The conversion of native Cerrado areas for the implementation of crops alters the physicochemical properties and biochemistry of soil. In this study we sought to understand the effect of seasonality and management used for planting sugarcane on the ...
Leciana de Menezes Sousa Zago   +5 more
doaj   +1 more source

Initial Velocity and Product Inhibition Studies on L-Iditol:NAD Oxidoreductase. [PDF]

open access: bronze, 1975
Ulla Christensen   +6 more
openalex   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

open access: yesAnimal Research and One Health, EarlyView.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao   +12 more
wiley   +1 more source

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