Results 81 to 90 of about 91,003 (373)

Biocatalytic Screening of the Oxidative Potential of Fungi Cultivated on Plant-Based Resources

AppliedChem
The environmental impacts of the postindustrial era, which rely on fossil fuels, have compelled a reconsideration of the future of energy and chemical industries.
Alina Kinner, Stephan Lütz, Katrin Rosenthal   +2 more
doaj   +1 more source

Periplasmic protein thiol:disulfide oxidoreductases of Escherichia coli [PDF]

, 2017
Disulfide bond formation is part of the folding pathway for many periplasmic and outer membrane proteins that contain structural disulfide bonds. In Escherichia coli, a broad variety of periplasmic protein thiol:disulfide oxidoreductases have been ...
Fabianek, Renata A., Hennecke, Hauke, Thöny-Meyer, Linda   +2 more
core  

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

Frontiers in Chemistry
Oxidoreductases play crucial roles in electron transfer during biological redox reactions. These reactions are not exclusive to protein-based biocatalysts; nano-size (<100 nm), fine-grained inorganic colloids, such as iron oxides and sulfides, also ...
Xiao-Lan Huang, Jeffrey R. Harmer, Gerhard Schenk, Gerhard Schenk, Gerhard Schenk, Gordon Southam, Gordon Southam   +6 more
doaj   +1 more source

The mechanism of catalysis by type-II NADH:quinone oxidoreductases

Scientific Reports, 2017
Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional respiratory complex I in ...
J. N. Blaza, H. R. Bridges, D. Aragão, Elyse Dunn, A. Heikal, G. Cook, Y. Nakatani, J. Hirst   +7 more
semanticscholar   +1 more source

Pharmacogenomics of human P450 oxidoreductase [PDF]

Frontiers in Pharmacology, 2014
Cytochrome P450 oxidoreductase (POR) supports reactions of microsomal cytochrome P450 which metabolize drugs and steroid hormones. Mutations in POR cause disorders of sexual development. P450 oxidoreductase deficiency (PORD) was initially identified in patients with Antley-Bixler syndrome (ABS) but now it has been established as a separate disorder of ...
Amit V Pandey, Amit V Pandey, Patrick eSproll   +2 more
openaire   +5 more sources

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Challenges and perspectives in using unspecific peroxygenases for organic synthesis

Frontiers in Catalysis
In the past 20 years, unspecific peroxygenases (UPOs) have emerged as promising biocatalysts for various organic transformations. Particularly, we have witnessed great attention being paid to the screening of new enzymes and expansion of the substrates ...
Yawen Huang, Yawen Huang, Jiangtao Sha, Jie Zhang, Jie Zhang, Wuyuan Zhang, Wuyuan Zhang, Wuyuan Zhang   +7 more
doaj   +1 more source

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

Frontiers in Microbiology, 2017
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis.
Blair Ney, Carlo R. Carere, R. Sparling, Thanavit Jirapanjawat, M. Stott, C. Jackson, J. Oakeshott, A. C. Warden, C. Greening   +8 more
semanticscholar   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source