Results 81 to 90 of about 10,063 (262)

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

‐(Diphenylphosphorothioyl)cycloalkanone Oximes

, 2020
International audienceA series of novel α-(diphenylphosphoryl)and α-(diphenylphosphorothioyl)cycloalkanone oximes have been synthesized in search for novel bioactive molecules.
Soufiane Touil, Kristof Van Hecke, Touil, Soufiane, Jebli, Nejib, Selma Hamimed, Nejib Jebli, Hamimed, Selma, Cavalier, Jean-François, Jean‐François Cavalier, van Hecke, Kristof   +9 more
core   +1 more source

The Influence of the Time of Antidotal Treatment Administration on the Potency of Newly Developed Oximes to Counteract Acute Toxic Effects of Tabun in Mice

Acta Medica, 2005
1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and newly developed oxime (K027 or K048) on its effectiveness to eliminate tabun-induced lethal toxic effects was studied in mice. 2.
Jiří Kassa
doaj   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Amidine−Oximes: Reactivators for Organophosphate Exposure

, 2016
A new class of amidine−oxime reactivators of organophosphate (OP)-inhibited cholinesterases (ChE) were designed, synthesized, and tested. These compounds represent a novel group of oximes with enhanced capabilities of crossing the blood−brain barrier ...
Jun Zhang (48506), Erik C. Ralph (2125897), John R. Cashman (354526), Jarosław Kalisiak (2125900)   +3 more
core   +1 more source

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Case Report of Acute Kidney Injury in Organophosphorus Poisoning and Potential Association with Oxime Use [PDF]

Asia Pacific Journal of Medical Toxicology
Introduction: Organophosphorus poisoning (OP) represents a significant public health issue, particularly in developing countries, due to its extensive availability and high toxicity.
Nourhan Saeed, Rania Youssef, Maram Mostafa   +2 more
doaj   +1 more source

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, EarlyView.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Determination of Stability for imines derived from carbonyl compounds by conductivity measurements

Tikrit Journal of Pure Science, 2018
The project explained for the first time, how conductivity method was used in the determination of stability of some imines derived from mother compounds 2-acetyl pyridine, 3 or 4 –hydroxy benzaldehyde, and others. The method as found, simple precise
A.S.P. Azzouz, D.B.AL-Bakzo
doaj   +1 more source

Fast Reduction of Nitroalkenes Into Nitroalkanes Under Continuous‐Flow Chemical Conditions

European Journal of Organic Chemistry, EarlyView.
Flow chemical synthesis was employed for the reduction of nitroalkenes to the corresponding nitroalkanes using sodium borohydride as the reducing agent. The reaction proceeds in only 150 s, affording products from good‐to‐excellent yields (61–96%). Herein, we describe an efficient and rapid continuous‐flow reduction of nitroalkenes to nitroalkanes. The
Iqra Munir, Gianmarco Simonelli, Marino Petrini, Alessandro Palmieri   +3 more
wiley   +1 more source