Results 61 to 70 of about 11,166 (254)
In Silico Identification of Hit Compound to Counteract A-Series Nerve Agents Poisoning
ChemistryOrganophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by phosphylating the catalytic serine. Oxime reactivators can restore enzymatic activity by a nucleophilic attack of the oximate anion on the ...
Nikola Maraković
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Acta Brasiliensis, 2017 Considering the therapeutic importance of the acetylcholinesterase inhibitor drugs, as well, enzyme regenerators drugs, in cases of organophosphate poisoning.
Maíra Dias Mangueira Bastos +3 more
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Erythromycin a oxime 11,12-carbonate and its oxime ethers.
The Journal of Antibiotics, 1989 Erythromycin A oxime 11,12-carbonate (5a) and its oxime ethers 5b approximately 5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and its 11,12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative ...
E G, Brain +4 more
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Molecules, 2017 The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa +6 more
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2,6-Dichlorobenzaldehyde oxime [PDF]
Acta Crystallographica Section E Structure Reports Online, 2008 In the title compound, C(7)H(5)Cl(2)NO, there are two mol-ecules in the asymmetric unit. The mol-ecules are essentially identical. Each mol-ecule is connected to a symmetry-related mol-ecule through an inversion center by O-H⋯N hydrogen bonds, building an R(2) (2)(6) graph-set motif.
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Structural Chemistry of Oximes
, 2016 Oximes (RR′CN–OH) represent an important class of organic compounds with a wide range of practical applications, but a systematic examination of the structural chemistry of such compounds has so far not been carried out.
Kanishka N. Epa (1952182) +5 more
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Steroidal Oximes and Cervical Cancer: An In Silico Mechanistic Pathway Approach
Scientia PharmaceuticaCervical cancer affects 661,000 women worldwide; as a result, new treatment alternatives are still being sought, with steroid oximes being the most prominent.
Carlos Antonio Sánchez-Valdeolivar +4 more
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Molecules, 2007 A novel and efficient method for the synthesis of N,N-dialkylamino/O-alkyl phenyl-2-(1-alkyl/phenyl-2-oxopropylidene) phosphonohydrazido oximes 4 using activated silica has been developed.
Mahabir P. Kaushik +2 more
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Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana +3 more
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BiomoleculesNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić +4 more
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