Results 71 to 80 of about 10,063 (262)

Structural Chemistry of Oximes

, 2016
Oximes (RR′CN–OH) represent an important class of organic compounds with a wide range of practical applications, but a systematic examination of the structural chemistry of such compounds has so far not been carried out.
Kanishka N. Epa (1952182), Michelle M. Smith (1952185), Abhijeet S. Sinha (1444234), John Desper (829596), Christer B. Aakeröy (1556743), Prashant D. Chopade (1952179)   +5 more
core   +1 more source

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

Molecules, 2017
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger, Jaroslav Pejchal   +6 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Steroidal Oximes and Cervical Cancer: An In Silico Mechanistic Pathway Approach

Scientia Pharmaceutica
Cervical cancer affects 661,000 women worldwide; as a result, new treatment alternatives are still being sought, with steroid oximes being the most prominent.
Carlos Antonio Sánchez-Valdeolivar, Alan Carrasco-Carballo, Jorge Organista-Nava, Jesús Sandoval-Ramírez, Berenice Illades-Aguiar   +4 more
doaj   +1 more source

The Influence of Anticholinergic Drug Selection on the Effectiveness of Oximes Against Soman-Induced Supralethal Poisoning in Mice

Acta Medica, 2001
1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
doaj   +1 more source

Oximes as reusable templates for the synthesis of ureas and carbamates by an in situ generation of carbamoyl oximes

, 2017
Oximes have been identified as reusable templates for the synthesis of ureas and carbamates by anin situgeneration of carbamoyl oximes under metal-free conditions.
Ting-Yi Lu, Gopal Chandru Senadi, Jeh-Jeng Wang, Mohana Reddy Mutra   +3 more
core   +1 more source

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Biomolecules
New furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik   +4 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Photocatalyzed Triplet Sensitization of Oximes Using Visible Light Provides a Route to Nonclassical Beckmann Rearrangement Products

, 2021
Oximes are valuable synthetic intermediates for the preparation of a variety of functional groups. To date, the stereoselective synthesis of oximes remains a major challenge, as most current synthetic methods either provide mixtures of E and Z isomers or
Xiao Zhang (152326), Tomislav Rovis (1308306), Xiao Zhang, Tomislav Rovis   +3 more
core   +1 more source

Ambident Reactivity in the Phenyl + NO Radical Recombination

Chemistry – A European Journal, EarlyView.
ABSTRACT The recombination reaction of nitric oxide (NO) with radicals via its oxygen atom, rather than the more common nitrogen site, offers an intriguing pathway to the formation of oxynitrenes. The photochemical isomerization of nitroso compounds into their corresponding oxynitrenes may involve such a step.
Virinder Bhagat, Adrián Portela‐González, André K. Eckhardt, J. Philipp Wagner   +3 more
wiley   +1 more source