Results 111 to 120 of about 46,956 (278)

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

PLOS ONE, 2015
We identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise Mrpl44 localization had been unclear.
Yeo, Janet H.C., Skinner, Jarrod P.J., Bird, Matthew J., Formosa, Luke E., Zhang, Jian- Guo, Kluck, Ruth M., Belz, Gabrielle T., Chong, Mark M.W.   +7 more
openaire   +7 more sources

Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source

Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system

BMC Genomics, 2008
Background The mitochondrial oxidative phosphorylation (OXPHOS) is critical for energy (ATP) production in eukaryotic cells. It was previously shown that genes coding for mitochondrial proteins involved in energy production co-express at the RNA level ...
Moraes Carlos T, van Waveren Corina
doaj   +1 more source

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Cell Reports, 2019
Summary: The plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations.
Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara Czako, Wylie S. Palmer, Faika Mseeh, John M. Asara, Yongying Jiang, Pietro Morlacchi, Shuping Zhao, Michael Peoples, Trang N. Tieu, Marc O. Warmoes, Philip L. Lorenzi, Florian L. Muller, Ronald A. DePinho, Giulio F. Draetta, Carlo Toniatti, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek   +37 more
doaj   +1 more source

Mitochondrial metabolism in Drosophila macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling

Biology Open, 2023
Shrivani Sriskanthadevan-Pirahas, Abdul Qadeer Tinwala, Michael J. Turingan, Shahoon Khan, Savraj S. Grewal   +4 more
doaj   +1 more source

Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models

Clinical and Translational Radiation Oncology
Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy ...
Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink   +7 more
doaj   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine
Oxidative phosphorylation (OXPHOS) plays a complex and dynamic role in cancer biology, with its involvement varying depending on tumor type, cancer progression stage, and microenvironmental conditions.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
doaj   +1 more source

The OXPHOS antibody labels respiratory complex proteins in Western blots and immunocytochemical experiments.

, 2015
(A) Representative immunoblot of OXPHOS antibody labeling, showing the expected 5 proteins in HeLa cells extracts, and proteins from the V, III, and II complexes in chicken DF1 fibroblasts.
Fabienne Pituello (42734), Marie-Christine Miquel (746393), Sophie Bel-Vialar (42732), Valérie Mils (746389), Julie Roy (746391), Pascale Belenguer (746392), Stéphanie Bosch (746390)   +6 more
core   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

LRPPRC confers enhanced oxidative phosphorylation metabolism in triple-negative breast cancer and represents a therapeutic target

Journal of Translational Medicine
Background Triple-negative breast cancer (TNBC) is a highly malignant tumor that requires effective therapeutic targets and drugs. Oxidative phosphorylation (OXPHOS) is a metabolic vulnerability of TNBC, but the molecular mechanism responsible for the ...
Qiqi Xue, Wenxi Wang, Jie Liu, Dachi Wang, Tianyu Zhang, Tingting Shen, Xiangsheng Liu, Xiaojia Wang, Xiying Shao, Wei Zhou, Xiaohong Fang   +10 more
doaj   +1 more source