Results 181 to 190 of about 46,956 (278)

Multi-omics analysis of long COVID (post-COVID-19 condition) reveals persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation. [PDF]

Front Immunol
Tasoula A, Arif S, Waisberg E, Bauer L, Aslinger E, Guarnieri JW.   +5 more
europepmc   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Metabolic gene expression-based stratification and prognostic risk predictive model of head and neck squamous cell carcinoma. [PDF]

NPJ Syst Biol Appl
Sau S, Gupta A, Sinha S, Mohiyuddin SMA, Korwar AM.   +4 more
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Intercellular mitochondrial transfer in melanoma progression and therapeutic resistance: mechanisms and targeting potential. [PDF]

Front Oncol
Yan Q, Sun T, Chen K, Hu H.
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine. [PDF]

Intensive Care Med Exp
Abele N, Merz T, Zink F, Hoffmann A, Gröger M, Kress S, Kranz S, Seifritz A, Passarelli V, Münz F, Feth M, Scheer M, Sharon O, Hogg M, Wolfschmitt EM, Wachter U, Schulz T, Calzia E, Fage N, Waller C, Asfar P, Radermacher P, Kapapa T.   +22 more
europepmc   +1 more source

Mitochondrial respiratory capacities are not linked to individual variation in hypoxia tolerance and standard metabolic rate in European seabass Dicentrarchus labrax

Journal of Fish Biology, EarlyView.
Abstract In hypoxic environments, fish attempt to regulate their metabolic rate as oxygen levels in the water decline. Individuals that have low energy requirements for maintenance – standard metabolic rate (SMR) – are expected to have higher hypoxia tolerance, measured as the critical water oxygen saturation threshold (Scrit) below which they cannot ...
Elisa Thoral, Julie Nati, Jean‐Baptiste Quémeneur, Léann Lozac'h, Germain Salou, Alain Vergnet, Mathieu Besson, Marc Vandeputte, François Allal, Karine Salin, David J. McKenzie, Loïc Teulier   +11 more
wiley   +1 more source

Potential roles of plant metabolites and Traditional Chinese Medicine formulas in regulating glycolysis-OXPHOS plasticity in gastric precancerous lesions and gastric cancer: a critical appraisal of the evidence. [PDF]

Front Pharmacol
Li S, Ma J, Ma C, Song Y, Chang L, Huo B.   +5 more
europepmc   +1 more source