Results 171 to 180 of about 51,375 (281)

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance. [PDF]

Cancer Med
Uti DE, Alum EU, Egbung JE, Mohammedsaleh ZM, Kaur M, Ealla KKR.   +5 more
europepmc   +1 more source

Characterisation of the OXPHOS-System in Melanoma

, 2016
Änderung des Energiemetabolismus zählt zu den „Emerging hallmarks of cancer“ und ist Gegenstand intensiver Forschung in jüngster Vergangenheit. Diese Arbeit beschäftigt sich mit der Frage, in welcher Form das maligne Melanom Energie gewinnt und welche ...
Rathje, Florian
core  

Mitochondrial retrograde signaling in gastric cancer: mtDNA mutations, ROS-driven NF-κB/HIF-1α activation, and Warburg effect amplification. [PDF]

Front Physiol
Bai Y, Chen W.
europepmc   +1 more source

Decreased Expression by a Chemically Modified siRNA to PTBP1 Seriously Affects Warburg Effect in Colorectal Cancer Cells

Cancer Science, EarlyView.
Chemically modified siR‐PTBP1 disrupts the Warburg effect by reprogramming pyruvate kinase splicing from PKM2 to PKM1. This metabolic shift activates the TCA cycle, increases ATP production, and excessive ROS generation, and ultimately induces apoptotic cell death in colorectal cancer cells.
Keita Matsumoto, Hirokatsu Hayashi, Yoshihisa Tokumaru, Seito Fujibayashi, Noriki Mitsui, Masahide Endo, Takeshi Horaguchi, Yuji Hatanaka, Ryoma Yokoi, Chika Mizutani, Masashi Kuno, Masahiro Fukada, Ryuichi Asai, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Yoshihiro Tanaka, Remi Nakashima, Yukihiro Akao, Nobuhisa Matsuhashi   +19 more
wiley   +1 more source

Weak but Repeated Patterns of Co-Introgression of Nuclear OXPHOS Genes and Mitochondrial DNA in Iberian Wall Lizards. [PDF]

Genome Biol Evol
Laizé M, Marques JP, Geniez P, Mochales-Riaño G, Kaliontzopoulou A, Muyle A, Pinho C, Crochet PA.   +7 more
europepmc   +1 more source

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

Cancer Science, EarlyView.
Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang, Wei Song, Qi Bai, Shaoze Shen, Xiao Lu, Chenxuan Su, Shi Yang, Yidi Wang, Yu Xia, Rui Zan, Shuai Jiang, Jianming Guo   +11 more
wiley   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Host systemic metabolism and cancer metabolic vulnerabilities: mechanisms and therapeutic opportunities. [PDF]

Front Oncol
Mir R, Barnawi J, Algehainy NA, M Jalal M, Altayar MA, Almotairi RM, Tayeb FJ, Moawadh MS, Bedaiwi RI, Almasoudi KS, Albalawi IA, Alasmari A, Mir MM.   +12 more
europepmc   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Single-cell transcriptomic signatures of T cells associated with rituximab responsiveness in idiopathic nephrotic syndrome. [PDF]

iScience
Koshi-Ito E, Watanabe Y, Onogi C, Horinouchi A, Ogami K, Yoshino S, Sugimoto Y, Komatsu S, Tanaka A, Furuhashi K, Maruyama S, Suzuki HI.   +11 more
europepmc   +1 more source