Results 171 to 180 of about 46,956 (278)

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Mitochondria transfer in glioblastoma. [PDF]

Neuro Oncol
Storevik S, Augustsson MT, Moreino S, Köppe H, Watson DC, Bayik D, De La Pena Fernandez C, Serapiglia AM, Panicker N, Lathia J, Miletic H.   +10 more
europepmc   +1 more source

Characterisation of the OXPHOS-System in Melanoma

, 2016
Änderung des Energiemetabolismus zählt zu den „Emerging hallmarks of cancer“ und ist Gegenstand intensiver Forschung in jüngster Vergangenheit. Diese Arbeit beschäftigt sich mit der Frage, in welcher Form das maligne Melanom Energie gewinnt und welche ...
Rathje, Florian
core  

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content. [PDF]

Elife
Frangos SM, Brunetta HS, Wang D, Jabile MJT, Jeffries LM, Mencfeld G, Ma DWL, Muller WJ, Khursigara CM, Fisher-Wellman KH, Petrik J, Steinberg GR, Holloway GP.   +12 more
europepmc   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Effects of Glyphosate and Roundup^® Herbicides on Cardiac and H9c2 Cells' Mitochondrial Respiration and Oxidative Stress. [PDF]

Int J Mol Sci
Rihani R, Charles AL, Oulehri W, Lejay A, Charloux A, Giannini M, Meyer A, Geny B.   +7 more
europepmc   +1 more source

Minimal Residual Disease as a Biological Trait: Rethinking Disease Persistence in Hematologic Malignancies

European Journal of Haematology, EarlyView.
ABSTRACT Minimal residual disease (MRD) has emerged as a central biomarker in hematologic malignancies, enabling highly sensitive detection of tumor persistence beyond conventional morphologic assessment and serving as an increasingly important surrogate endpoint in clinical trials.
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +14 more
wiley   +1 more source

Cyclin-Dependent Kinase-9 and Oxidative Phosphorylation Inhibition Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma. [PDF]

Cancer Res Commun
Roleder C, Zhao X, Lam V, Shen H, Dominguez EC, Chen C, Rodriguez-Rodriguez S, Wang L, Phillips T, Xia Z, Danilov AV.   +10 more
europepmc   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source