Results 241 to 250 of about 60,467 (293)

Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting. [PDF]

Front Oncol
Huang W, Sun W, Yang Z, Li Y, Wang Z.
europepmc   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy. [PDF]

J Clin Invest
Adachi Y, Chen W, Zhang C, Wang T, Gildor N, Shi R, Fu H, Takeda M, Liang Q, Zhao F, Liu H, Fang J, Zhou J, Yao H, Hu L, Li S, Guo L, Xu L, Xie L, Chen X, Liao C, Zhang Q.   +21 more
europepmc   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

Metformin induces ferroptosis associated with lipidomic remodeling in AML. [PDF]

Blood Adv
Sternadt D, Pereira-Martins DA, Chatzikyriakou P, Albuquerque-Simões L, Yang M, Silveira DRA, Wierenga ATJ, Weinhäuser I, Hogeling SM, Oudejans LL, Casares Alaez P, Sarry JE, Frezza C, Huls GA, Quek L, Schuringa JJ.   +15 more
europepmc   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Specific SLC25 carriers regulate mitochondrial protein synthesis. [PDF]

Sci Adv
Rudler DL, Hughes LA, King MS, Baker J, Lee RG, Gandadireja AP, Sunil A, Fagan SV, Payne B, Gray N, McCubbin T, Kunji ERS, Rackham O, Filipovska A.   +13 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease. [PDF]

Front Immunol
Getachew F, Hu J, Benamar M.
europepmc   +1 more source