Results 241 to 250 of about 46,956 (278)

AATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism. [PDF]

open access: yesCell Death Dis
Sorino C   +15 more
europepmc   +1 more source

Mitochondrial Adaptations in Skeletal Muscle Following Incretin-Based Therapies: In Vitro. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
Old V   +6 more
europepmc   +1 more source
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Immortalizing switch to OXPHOS

Nature Reviews Molecular Cell Biology, 2020
The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.
Paulina Strzyz, Strzyz Paulina
exaly   +3 more sources

OXPHOS inhibitors, metabolism and targeted therapies in cancer

Biochemical Pharmacology, 2023
More and more studies highlight the complex metabolic characteristics and plasticity of cancer cells. To address these specificities and explore the associated vulnerabilities, new metabolism-targeting therapeutic strategies are being developed. It is more and more accepted that cancer cells do not produce their energy only from aerobic glycolysis, as ...
Cadassou, Octavia, Jordheim, Lars Petter
openaire   +2 more sources

Mitochondrial OXPHOS complex assembly lines

Nature Cell Biology, 2018
Mitochondria are critical for cellular energy generation and house oxidative phosphorylation (OXPHOS) complexes, which are under dual genetic control. A study finds that transcript translation and complex assembly are partitioned, and OXPHOS complexes III, IV and V are built at spatially defined regions of the mitochondrial inner membrane.
Luke E, Formosa, Michael T, Ryan
openaire   +2 more sources

OXPHOS gene expression and control in mitochondrial disorders

open access: yesBiochimica Et Biophysica Acta - Molecular Basis of Disease, 2009
The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca(2+), ADP/ATP, and NAD/NADH. The adaptive responses to these changes include the transcriptional responses of nuclear and mitochondrial genes that are mediated by these metabolites ...
François H Van Der Westhuizen
exaly   +4 more sources

OXPHOS and mtDNA alterations in a family with spastic paraparesis

Acta Neurologica Scandinavica, 2000
To study muscle biopsies in hereditary spastic paraparesis (HSP).We analyzed oxidative phosphorylation activities and mtDNA in 3 individuals from an HSP family.We found histochemical evidence for mitochondrial proliferation and cytochrome c oxidase negative fibers.
F M, Santorelli   +6 more
openaire   +2 more sources

OXPHOS Supercomplexes

Annals of the New York Academy of Sciences, 2006
Abstract:  Recent biochemical evidence has indicated the existence of respiratory supercomplexes as well as ATP synthase oligomers in the inner mitochondrial membrane of different eukaryotes. We have studied the organization of the respiratory chain of a wild‐type strain and of two long‐lived mutants of the filamentous fungus Podospora anserina.
Frank, Krause   +6 more
openaire   +2 more sources

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