Results 241 to 250 of about 51,375 (281)
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
Cell Reports Medicine, 2020 International audienceHighlights d Pancreatic ductal adenocarcinoma (PDAC) displays OXPHOS heterogeneity d High OXPHOS PDAC tumors are enriched in mitochondrial respiratory complex I d Complex I inhibitor phenformin synergizes with chemotherapy in high ...
Alice Carrier +2 more
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Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications [PDF]
Seminars in Cancer Biology, 2022 Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation ...
Simon R Lord +2 more
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Immortalizing switch to OXPHOS
Nature Reviews Molecular Cell Biology, 2020The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.
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Mitochondrial OXPHOS complex assembly lines
Nature Cell Biology, 2018Mitochondria are critical for cellular energy generation and house oxidative phosphorylation (OXPHOS) complexes, which are under dual genetic control. A study finds that transcript translation and complex assembly are partitioned, and OXPHOS complexes III, IV and V are built at spatially defined regions of the mitochondrial inner membrane.
Luke E, Formosa, Michael T, Ryan
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OXPHOS gene expression and control in mitochondrial disorders
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2009 The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca(2+), ADP/ATP, and NAD/NADH. The adaptive responses to these changes include the transcriptional responses of nuclear and mitochondrial genes that are mediated by these metabolites ...
Francois van der Westhuizen
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Annals of the New York Academy of Sciences, 2006
Abstract: Recent biochemical evidence has indicated the existence of respiratory supercomplexes as well as ATP synthase oligomers in the inner mitochondrial membrane of different eukaryotes. We have studied the organization of the respiratory chain of a wild‐type strain and of two long‐lived mutants of the filamentous fungus Podospora anserina.
Frank, Krause +6 more
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Abstract: Recent biochemical evidence has indicated the existence of respiratory supercomplexes as well as ATP synthase oligomers in the inner mitochondrial membrane of different eukaryotes. We have studied the organization of the respiratory chain of a wild‐type strain and of two long‐lived mutants of the filamentous fungus Podospora anserina.
Frank, Krause +6 more
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Biochemical Diagnosis of OXPHOS Disorders
2004In this chapter the biochemical diagnosis of OXPHOS disorders is presented. The laboratory investigations in suspected patients are started with the examination of body fluids. The most important metabolite to be measured is lactate, that is frequendy found to be elevated in blood, urine and cerebrospinal fluid of patients with OXPHOS disorders.
J. M. Frans Trijbels +4 more
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Blue-Native Electrophoresis to Study the OXPHOS Complexes
2020Blue-native polyacrylamide gel electrophoresis (BN-PAGE) is a technique optimized for the analysis of the five components of the mitochondrial oxidative phosphorylation (OXPHOS) system. BN-PAGE is based on the preservation of the interactions between the individual subunits within the integral complexes.
Fernandez-Vizarra, Erika +1 more
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OXPHOS and mtDNA alterations in a family with spastic paraparesis
Acta Neurologica Scandinavica, 2000To study muscle biopsies in hereditary spastic paraparesis (HSP).We analyzed oxidative phosphorylation activities and mtDNA in 3 individuals from an HSP family.We found histochemical evidence for mitochondrial proliferation and cytochrome c oxidase negative fibers.
F M, Santorelli +6 more
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Mitochondrial DNA and OXPHOS Disorders
2007Mitochondrial OXPHOS is at the crosspoint of two quite different genetic systems, the nuclear genome, and the mitochondrial genome (mitochondrial DNA, mtDNA). The latter encodes a few essential components of the mitochondrial respiratory chain, and has unique molecular and genetic properties that account for some of the peculiar features of ...
Massimo Zeviani, Valerio Carelli
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