Results 91 to 100 of about 65,167,055 (305)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Current Indiana Oxygen Headquarters, Indianapolis

, 1990
As Indiana Oxygen grew, it began to open satellite branch stores, the first in Muncie in 1978. The increased demand for gas products required Indiana Oxygen to move again in 1991 to a new state-of-the-industry palletized cylinder fill plant on ...

core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Declining Oxygen in the World's Ocean and Coastal Waters

, 2018
Oxygen is critical to the health of the ocean. It structures aquatic ecosystems and is a fundamental requirement for marine life from the intertidal zone to the greatest depths of the ocean. Oxygen is declining in the ocean.
Gilbert, Denis, Yasuhara, Moriaki, Chavez, Francisco, Naqvi, Wajih, Rabalais, Nancy, Telszewski, Maciej, Garçon, Véronique, Seibel, Brad, Levin, Lisa, Limburg, Karin, Zhang, Jing, Gutierrez, Dimitri, Isensee, Kirsten, Rose, Kenny, Pitcher, Grant, Jacinto, Gil, Conley, Daniel, Montes, Ivonne, Oschlies, Andreas, Roman, Mike   +19 more
core  

Stable isotope signatures of deuterium, oxygen 18, and carbon 13 (δ²H, δ ¹⁸O, δ ¹³C) in imported apples available in the markets of Vietnam. [PDF]

Food Chem X, 2023
Lan Anh H, Duc Nhan D, Minh Quynh T.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Employing artificial intelligence to predict δ¹⁸O and δ²H isotope ratios in precipitation in Iraq under changing climate patterns

Scientific Reports
Understanding precipitation dynamics in arid regions such as Iraq is of paramount importance in hydrological and climatological studies, as it is a key approach to water resources management and climate change adaptation.
Ali Al Maliki, Ali Al-Naji, Ahmed Kadhim Al Lami, Haitham Abdulmohsin Afan, Maryam Bayatvarkeshi, Nadhir Al-Ansari   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Spatial oxygen heterogeneity in a Hediste diversicolor irrigated burrow [PDF]

, 2011
The heterogeneity of oxygen distribution in a Hediste diversicolor burrow environment was investigated in a laboratory experiment using a 6-mm thick tank equipped with oxygen planar optodes. The twodimensional oxygen distribution in a complete burrow was
Franck Gilbert, Poggiale, Jean-Christophe, Cuny, Philippe, Esteves, José Luis, Philippe Cuny, José Luis Esteves, Gilbert, Franck, Laura Pischedda, Jean-Christophe Poggiale, Pischedda, Laura, Esteves, Josã© Luis, Poggiale, Jean Christophe   +11 more
core   +1 more source