Results 41 to 50 of about 1,387,037 (263)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Stable isotope mass balance of fifty lakes in central Alberta: Assessing the role of water balance parameters in determining trophic status and lake level

open access: yesJournal of Hydrology: Regional Studies, 2016
Study region: This study spans the Prairie/parkland/boreal transition in central Alberta, including lakes in the Athabasca, North Saskatchewan, Battle River and Red Deer Basins.
J.J. Gibson   +4 more
doaj   +1 more source

Spatial distribution of oxygen-18 and deuterium in stream waters across the Japanese archipelago [PDF]

open access: yesHydrology and Earth System Sciences, 2015
The spatial distribution of oxygen and hydrogen isotopic composition (δ18O and δ2H) of stream waters across Japan was clarified with a data set by compiling sample data obtained from 1278 forest catchments during the summer of 2003.
M. Katsuyama, T. Yoshioka, E. Konohira
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Hydrochemical and isotope groundwater investigations in Sorško polje

open access: yesGeologija, 2008
From the hydrogeological point of view Sorško polje area is a sink, filled with conglomerate,sandand gravel,where large quantities of groundwater are accumulated.
Brigita Jamnik, Janko Urbanc
doaj  

Planetary fertility during the past 400 ka based on the triple isotope composition of O2 in trapped gases from the Vostok ice core [PDF]

open access: yesClimate of the Past, 2012
The productivity of the biosphere leaves its imprint on the isotopic composition of atmospheric oxygen. Ultimately, atmospheric oxygen, through photosynthesis, originates from seawater.
J. C. von Fischer   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Isotopes of oxygen-18 and deuterium in precipitation in Slovakia / Izotopy kyslíka-18 A deutéria v zrážkach na Slovensku

open access: yesJournal of Hydrology and Hydromechanics, 2012
Príspevok syntetizuje dostupné údaje o izotopickom zložení zrážok na území Slovenska (Západné Karpaty). Hodnotí koreláciu hodnôt δ18O v kumulatívnych mesačných zrážkach z rokov 1988-1997 medzi jednotlivými stanicami, vplyv nadmorskej výšky, teploty ...
Holko Ladislav   +3 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy