Results 61 to 70 of about 5,363,213 (311)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Oxygen isotope fractionation during N₂O production by soil denitrification [PDF]

Biogeosciences, 2016
The isotopic composition of soil-derived N2O can help differentiate between N2O production pathways and estimate the fraction of N2O reduced to N2. Until now, δ18O of N2O has been rarely used in the interpretation of N2O isotopic signatures because of ...
D. Lewicka-Szczebak, J. Dyckmans, J. Kaiser, A. Marca, J. Augustin, R. Well   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dynamics Of Seasonal Patterns In Geochemical, Isotopic, And Meteorological Records Of The Elbrus Region Derived From Functional Data Clustering

Geography, Environment, Sustainability, 2020
A nonparametric clustering method, the Bagging Voronoi K-Medoid Alignment algorithm, which simultaneously clusters and aligns spatially/temporally dependent  curves,  is applied to study various data series from the Elbrus  region (Central Caucasus).
Gleb A. Chernyakov, Valeria Vitelli, Mikhail Y. Alexandrin, Alexei M. Grachev, Vladimir N. Mikhalenko, Anna V. Kozachek, Olga N. Solomina, V. V. Matskovsky   +7 more
doaj   +1 more source

Part of the global seawater delta oxygen-18 database from reference Punning 1991

, 2001
Part of the global seawater delta oxygen-18 database from reference Punning ...
Ya-M K Punning (6970652), Punning, Ya-M K   +1 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Oxygen: problems and solutions in electrochemistry

, 2013
Different aspects of the electrochemistry of oxygen are examined through four experimental examples: corrosion, passivation via organic thin films, oxygen reduction and water oxidation catalysis are outlined in order to outline the very different ...
Bardini, Luca <1985>
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Milk Authentication: Stable Isotope Composition of Hydrogen and Oxygen in Milks and Their Constituents

Molecules, 2020
This paper summarises the isotopic characteristics, i.e., oxygen and hydrogen isotopes, of Slovenian milk and its major constituents: water, casein, and lactose.
Staša Hamzić Gregorčič, Doris Potočnik, Federica Camin, Nives Ogrinc   +3 more
doaj   +1 more source

(Table 1) Oxygen-18 distribution in waters of the Arctic Ocean in 1967 and 1969

, 1974
(Table 1) Oxygen-18 distribution in waters of the Arctic Ocean in 1967 and ...
Malyuk, GA, GA Malyuk (7970618), Vetshteyn, V Y, Rusanov, V P, V Y Vetshteyn (7892687), V P Rusanov (7970621)   +5 more
core   +1 more source