Results 61 to 70 of about 6,998,665 (296)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Part of the global seawater delta oxygen-18 database from reference Frohlich 1988

open access: yes, 2001
Part of the global seawater delta oxygen-18 database from reference Frohlich ...
Frohlich, K, K Frohlich (7892732)
core   +1 more source

Biomass effects on oxygen transfer in membrane bioreactors [PDF]

open access: yes, 2007
Ten biomass samples from both municipal and industrial pilot and full scale submerged membrane bioreactors (MBRs) with mixed liquor suspended solids concentrations (MLSS) ranging from 7.2 to 30.2 g L−1 were studied at six air-flow rates (0.7, 1.3, 2.3, 3,
Nelles, F.   +7 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Serum interleukin-18 levels are associated with physical activity in Japanese men.

open access: yesPLoS ONE, 2013
ObjectiveTo investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men.MethodsA total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study.
Kanae Oda   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Oxygen isotope fractionation during N2O production by soil denitrification [PDF]

open access: yesBiogeosciences, 2016
The isotopic composition of soil-derived N2O can help differentiate between N2O production pathways and estimate the fraction of N2O reduced to N2. Until now, δ18O of N2O has been rarely used in the interpretation of N2O isotopic signatures because of ...
D. Lewicka-Szczebak   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Dynamics Of Seasonal Patterns In Geochemical, Isotopic, And Meteorological Records Of The Elbrus Region Derived From Functional Data Clustering

open access: yesGeography, Environment, Sustainability, 2020
A nonparametric clustering method, the Bagging Voronoi K-Medoid Alignment algorithm, which simultaneously clusters and aligns spatially/temporally dependent  curves,  is applied to study various data series from the Elbrus  region (Central Caucasus).
Gleb A. Chernyakov   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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