Results 51 to 60 of about 1,387,037 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Serum interleukin-18 levels are associated with physical activity in Japanese men.

PLoS ONE, 2013
ObjectiveTo investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men.MethodsA total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study.
Kanae Oda, Nobuyuki Miyatake, Noriko Sakano, Takeshi Saito, Motohiko Miyachi, Izumi Tabata, Takeyuki Numata   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Oxygen isotope fractionation during N₂O production by soil denitrification [PDF]

Biogeosciences, 2016
The isotopic composition of soil-derived N2O can help differentiate between N2O production pathways and estimate the fraction of N2O reduced to N2. Until now, δ18O of N2O has been rarely used in the interpretation of N2O isotopic signatures because of ...
D. Lewicka-Szczebak, J. Dyckmans, J. Kaiser, A. Marca, J. Augustin, R. Well   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dynamics Of Seasonal Patterns In Geochemical, Isotopic, And Meteorological Records Of The Elbrus Region Derived From Functional Data Clustering

Geography, Environment, Sustainability, 2020
A nonparametric clustering method, the Bagging Voronoi K-Medoid Alignment algorithm, which simultaneously clusters and aligns spatially/temporally dependent  curves,  is applied to study various data series from the Elbrus  region (Central Caucasus).
Gleb A. Chernyakov, Valeria Vitelli, Mikhail Y. Alexandrin, Alexei M. Grachev, Vladimir N. Mikhalenko, Anna V. Kozachek, Olga N. Solomina, V. V. Matskovsky   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A seasonal precipitation isoscape for New Zealand

Journal of Hydrology: Regional Studies
Region: New Zealand Focus: Application of a seasonal precipitation isoscape for New Zealand, to incorporate influences of regional scale atmospheric circulation, and local topography.
B.D. Dudley, A.F. Hill, A. McKenzie
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Interpretation of groundwater origin in the Velenje coal mine on the basis of isotope composition

Geologija, 2002
The aim of the investigation was to determine the isotopic properties of cave waters from the Velenje coal mine and define the recharge areas of individual aquifers.
Janko Urbanc, Bojan Lajlar
doaj