Results 171 to 180 of about 27,463 (211)

Oxygen-induced retinopathy in the rat model

Documenta Ophthalmologica, 1990
Identification of a suitable animal model is essential for the continued study of retinopathy of prematurity (ROP). Since 1984 we have used the newborn rat for the study of oxygen-induced retinopathy (OIR). The rat retina is highly immature at birth. Like those of humans, the retinal vessels arise from mesenchymal precursors, but contrary to that which
Benedetto Ricci, Ricci Benedetto
exaly   +3 more sources

Blood Vessel Maturation by Disintegrin in Oxygen-Induced Retinopathy

Current Eye Research, 2015
Although Arg-Gly-Asp (RGD) motif-containing disintegrins are associated with integrin inhibition and the activation of various biological processes, little is known about the role of RGD motif-containing disintegrin in vascular development and remodeling.
Doo-Sik Kim
exaly   +3 more sources

Animal models of oxygen-induced retinopathy

Frontiers in Bioscience, 2003
Retinopathy of prematurity (ROP) is a neovascularizing disease of the retina affecting premature infants. Much of our current knowledge regarding development of both normal and abnormal blood vessels in the retina has been obtained from animal models of retinopathy. The retina is an excellent organ for studying angiogenesis, since the progress of blood
Ashima, Madan, John S, Penn
openaire   +2 more sources

Oxygen-Induced Retinopathy in the Rat

1988
Through a decade of research, peroxidation has been implicated in human retinal degenerations. Ocular siderosis, or iron in the eye, has long been known to result in retinal degeneration. Certain retinotoxic drugs, such as adriamycin, are believed to act by peroxidative mechanisms.
J S, Penn, L A, Thum
openaire   +2 more sources

Hereditary influences in oxygen-induced retinopathy in the rat

Documenta Ophthalmologica, 2009
Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a ...
Coster, Douglas John, van Wijngaarden, Peter, Williams, Keryn Anne, Brereton, Helen Mary   +3 more
openaire   +3 more sources

Induction and Readout of Oxygen-Induced Retinopathy

2019
Ischemic retinal diseases can be caused by various pathologies, which often lead to formation of preretinal neovascularization. A very common and well-established model to study normal as well as pathological angiogenic mechanisms in retina is the oxygen-induced retinopathy model in mice.
Raffael, Liegl, Claudia, Priglinger, Andreas, Ohlmann   +2 more
openaire   +2 more sources

The anatomy of the rat eye with oxygen-induced retinopathy

Documenta Ophthalmologica, 2009
Prior studies have documented the intertwined developmental courses of retinal blood vessel tortuosity (in fundus photographs) and retinal dysfunction (in electroretinographs) in Sprague-Dawley rat models of retinopathy of prematurity (ROP). Two such models, the "50/10 model" and the "75 model," are named after the oxygen regimens used to induce ...
James D, Akula, Tara L, Favazza, Julie A, Mocko, Ilan Y, Benador, Ana L, Asturias, Michael S, Kleinman, Ronald M, Hansen, Anne B, Fulton   +7 more
openaire   +2 more sources

Models of Oxygen Induced Retinopathy in Rodents

2016
Much of the knowledge we have gained into the development of pathological ocular angiogenesis has come from the development of in vivo models that enable functional assessment of key components of signaling pathways in disease progression. Indeed, rodent models have facilitated identification of several therapeutics that target pathological ...
Melissa V, Gammons, David O, Bates
openaire   +2 more sources

Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy

Documenta Ophthalmologica, 2009
Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all ...
Elsa, Kermorvant-Duchemin, Przemyslaw, Sapieha, Mirna, Sirinyan, Martin, Beauchamp, Daniella, Checchin, Pierre, Hardy, Florian, Sennlaub, Pierre, Lachapelle, Sylvain, Chemtob   +8 more
openaire   +2 more sources