Results 211 to 220 of about 4,357,227 (243)

Hereditary influences in oxygen-induced retinopathy in the rat

Documenta Ophthalmologica, 2009
Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a ...
Coster, Douglas John, van Wijngaarden, Peter, Williams, Keryn Anne, Brereton, Helen Mary   +3 more
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The anatomy of the rat eye with oxygen-induced retinopathy

Documenta Ophthalmologica, 2009
Prior studies have documented the intertwined developmental courses of retinal blood vessel tortuosity (in fundus photographs) and retinal dysfunction (in electroretinographs) in Sprague-Dawley rat models of retinopathy of prematurity (ROP). Two such models, the "50/10 model" and the "75 model," are named after the oxygen regimens used to induce ...
James D, Akula, Tara L, Favazza, Julie A, Mocko, Ilan Y, Benador, Ana L, Asturias, Michael S, Kleinman, Ronald M, Hansen, Anne B, Fulton   +7 more
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Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy

Documenta Ophthalmologica, 2009
Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all ...
Elsa, Kermorvant-Duchemin, Przemyslaw, Sapieha, Mirna, Sirinyan, Martin, Beauchamp, Daniella, Checchin, Pierre, Hardy, Florian, Sennlaub, Pierre, Lachapelle, Sylvain, Chemtob   +8 more
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The effect of cryotherapy on oxygen‐induced retinopathy in the newborn kitten

Acta Ophthalmologica, 1987
Abstract. Partial cryotherapy was performed in the right eye of 14 kittens with experimental oxygen‐induced retinopathy, while the left eye remained untreated as a control. Subsequent funduscopic examination and histopathological studies of all kittens showed no significant difference between the treated and untreated eyes with respect to the amount ...
I, Kremer, R, Kissun, I, Nissenkorn, I, Ben-Sira, A, Garner   +4 more
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Oxygen-induced retinopathy in the rat model

Documenta Ophthalmologica, 1990
Identification of a suitable animal model is essential for the continued study of retinopathy of prematurity (ROP). Since 1984 we have used the newborn rat for the study of oxygen-induced retinopathy (OIR). The rat retina is highly immature at birth. Like those of humans, the retinal vessels arise from mesenchymal precursors, but contrary to that which
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Hydrogen-rich Saline is ineffective in oxygen-induced retinopathy

Life Sciences, 2016
Hydrogen-rich saline (HRS) is a novel protection against various oxidative disorders and almost all types of inflammation. Moreover, its toxicity and side effects are rarely reported. We sought to clarify the protective effect of HRS against the oxygen-induced retinopathy (OIR) in C57BL/6 J model.The OIR in the HRS treated mice and the untreated ...
Qian, Zhang, Ye, Tao, Zuo-Ming, Zhang
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Ibuprofen improves oxygen-induced retinopathy in a mouse model

Current Eye Research, 2003
Retinopathy of prematurity is a developmental vascular anomaly occurring in the incompletely vascularized retina of the premature infant. Ibuprofen is a nonsteroidal anti-inflammatory agent similar to indomethacin, but with less pronounced side-effects.
Jotishna, Sharma, Sybil M, Barr, Yixun, Geng, Yan, Yun, Rosemary D, Higgins   +4 more
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Impaired nephrogenesis in neonatal rats with oxygen‐induced retinopathy

Pediatrics International, 2017
AbstractBackgroundPreterm neonates are born while nephrogenesis is ongoing, and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP).
Mayu Nakagawa, Naoto Nishizaki, Amane Endo, Tomonosuke Someya, Yuta Saito, Akira Mizutani, Taichi Hara, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Daisuke Umino, Daishi Hirano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu   +14 more
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Rodent Models of Oxygen-Induced Retinopathy

2008
Retinopathy of prematurity (ROP), a condition affecting premature infants, is characterized by pathological ocular angiogenesis, or retinal neovasculariztion (NV). Much of what is known about the development of the retinal vasculature and the progression of ROP has been acquired through the use of animal models of oxygen-induced retinopathy (OIR ...
Susan E. Yanni, Gary W. McCollum, John S. Penn   +2 more
openaire   +1 more source

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Journal of Visualized Experiments, 2020
One of the commonly used models for ischemic retinopathies is the oxygen-induced retinopathy (OIR) model. Here we describe detailed protocols for the OIR model induction and its readouts in both mice and rats. Retinal neovascularization is induced in OIR by exposing rodent pups either to hyperoxia (mice) or alternating levels of hyperoxia and hypoxia ...
Maria, Vähätupa, Niina, Jääskeläinen, Marc, Cerrada-Gimenez, Rubina, Thapa, Tero, Järvinen, Giedrius, Kalesnykas, Hannele, Uusitalo-Järvinen   +6 more
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