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Observations of Vitamin E in Experimental Oxygen—Induced Retinopathy
Ophthalmology, 1979Retrolental fibroplasia (RLF) is a proliferative retinopathy observed in premature infants. Its relationship to oxygen has led to both clinical and laboratory research into the potential benefits of the antioxidant tocopherol in this disorder. Although the clinical trials to date have only suggested a beneficial result, studies in the kitten model ...
D L, Phelps, A L, Rosenbaum
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The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model
Pediatrics, 1977The effect of tocopherol (vitalnin E) on oxygen-induced retinopathy was studied in 75 kittens following the development of a 12-point scoring system to quantitate the degree of retinopathy seen at three weeks. The tocopherol was found to be beneficial when given daily from the day of birth (P < .0001) with oxygen exposures of two to three days ...
D L, Phelps, A L, Rosenbaum
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[Four newborns with retinopathy similar to oxygen-induced retinopathy].
Nippon Ganka Gakkai zasshi, 1998We report 4 fullterm newborns who developed retinopathy similar to oxygen-induced retinopathy after high concentration oxygen therapy for pneumothorax and emphysema. Two of them had a severe condition, showing marked dilatation, winding, and abnormal branching of the retinal vessels, especially veins, and retinal trubidity.
H, Ota, H, Sannan, K, Taoka, Y, Uji
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[Quantification of oxygen-induced retinopathy in the mouse].
Yan ke xue bao = Eye science, 2007To establish a quantifying model of retinal neovascularization suitable for examining pathogenesis and therapeutic intervention for the retinal neovascularization.Sixty 7-day-old C57BL/6J mice were divided into oxygen-induced retinopathy group and control group.
Yi, Liu +5 more
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The Mouse Model of Oxygen-Induced Retinopathy (OIR)
2012The mouse model of oxygen-induced retinopathy (OIR) is a well established model to study retinal angiogenesis. It has been used extensively to investigate the mechanisms behind pathologic vessel formation in the eye and has helped to lay the foundations for clinical trials.
Andreas Stahl +3 more
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Oxygen induced retinopathy (OIR) mouse model
Acta Ophthalmologica, 2012AbstractPurpose To introduce mouse model for oxygen induced retinopathy (OIR).Methods Newborn mice are exposed to 75 % oxygen at P7 for 5 days. High oxygen level leads to regression of retinal vasculature and large avascular areas of retina. At P12, upon return to normoxia avascular retinal areas become ischemic.
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Effect of dual PPAR-α/γ agonist saroglitazar on diabetic retinopathy and oxygen-induced retinopathy
European Journal of Pharmacology, 2021Mukul Jain +2 more
exaly
Oxygen-induced proliferative retinopathy in the newborn rat.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1990The neonatal rat, which has an immature retinal vasculature at the time of birth, is a potential animal model for retinopathy of prematurity since it has an established spindle cell retinal vasoformation pattern similar to that seen in the human. To determine if proliferative oxygen-induced retinopathy can be produced in the rat, 40 newborn rat pups ...
M R, Ventresca +2 more
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[A modified mouse model of oxygen-induced retinopathy].
Yan ke xue bao = Eye science, 2007To set up a simple and effective oxygen-induced retinopathy (OIR) mouse model.Eyes from P17 mice in modified OIR group(Group A)and traditional OIR group (Group B) were snap frozen for immunohistochemical analysis with antibodies against GSL Flat-mounted, fluorescein-conjugated dextran-perfused retinas were examined to assess the retinal vasculature ...
Xiaoyan, Ding +4 more
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