Results 71 to 80 of about 509,742 (296)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Recent Advances in Oxygen Electrocatalysts Based on Perovskite Oxides

Nanomaterials, 2019
Electrochemical oxygen reduction and oxygen evolution are two key processes that limit the efficiency of important energy conversion devices such as metal−air battery and electrolysis.
Jun Xu, Chan Chen, Zhifei Han, Yuanyuan Yang, Junsheng Li, Qibo Deng   +5 more
doaj   +1 more source

Study of the influence of phosphoric acid in steel anaerobic corrosion via the hydrogen evolution reaction. [PDF]

, 2007
Although it is well known that the phosphate species are quiet electrochemically inert when considering their calculated redox potential, few studies since the end of 80’s reported electrochemical phenomenon observed in the reduction domain which were ...
Basséguy, Régine, Bergel, Alain, De Silva Munoz, Leonardo   +2 more
core  

Chemical and photochemical properties of chloroharmine derivatives in aqueous solutions [PDF]

, 2016
Thermal and photochemical stability (ΦR), room temperature UV-vis absorption and fluorescence spectra, fluorescence quantum yields (ΦF) and lifetimes (τF), quantum yields of hydrogen peroxide (ΦH2O2) and singlet oxygen (ΦΔ) production, and triplet ...
Cabrerizo, Franco Martín, Denofrio, Maria Paula, Erra Balsells, Rosa, Gonzalez, Maria Micaela, Rasse Suriani, Federico Ariel Osvaldo, Seifermann, Marco, Wolcan, Ezequiel, Yañuk, Juan Gabriel   +7 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Origin and evolution of water oxidation before the last common ancestor of the Cyanobacteria [PDF]

, 2015
Photosystem II, the water oxidizing enzyme, altered the course of evolution by filling the atmosphere with oxygen. Here, we reconstruct the origin and evolution of water oxidation at an unprecedented level of detail by studying the phylogeny of all D1 ...
A. William Rutherford, Anisimova, Arato, Arnold, Bader, Beanland, Blankenship, Campbell, Cardona, Cardona, Chu, Chu, Clausen, Cox, Criscuolo, Cser, Dagan, Dau, Debus, Debus, Deusch, Diner, Dismukes, Erickson, Ferreira, Fine, Flannery, Gan, Gan, Giorgi, Gould, Gouy, Guindon, Gupta, Guskov, Hasegawa, Hillier, Hoganson, Hohmann-Marriott, Huson, Ishikita, Ishikita, James W. Murray, Jia, Johnson, Kiss, Klimov, Kopp, Koyama, Kulkarni, Kuroda, Lambreva, Larom, Larsson, Lartillot, Lee, Lidholm, Linke, Loll, Lyons, Marin, Merry, Metz, Michel, Michel, Mimuro, Muh, Mulo, Mulo, Murray, Murray, Nakamura, Nitschke, Nixon, Nixon, Nixon, Ochoa de Alda, Oettmeier, Ogami, Park, Petrouleas, Qian, Rappaport, Rasmussen, Raymond, Rippka, Robinson, Rodriguez-Ezpeleta, Roose, Rutherford, Rutherford, Saito, Sauer, Saw, Sedoud, Service, Shevela, Shi, Shih, Sicora, Sicora, Siegbahn, Sievers, Sugiura, Sugiura, Sugiura, Sugiura, Summerfield, Tanai Cardona, Tichy, Toepel, Turner, Ulas, Umena, Vass, Vassiliev, Vermaas, Vermaas, Vermaas, Vinyard, Waldbauer, Wegener, Yoon, Zehr, Zhang, Zhang, Zimmermann   +126 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Electrocatalysts based on metal@carbon core@shell nanocomposites: An overview

Green Energy & Environment, 2018
Developing low-cost, high-performance catalysts is of fundamental significance for electrochemical energy conversion and storage. In recent years, metal@carbon core@shell nanocomposites have emerged as a unique class of functional nanomaterials that show
Yi Peng, Shaowei Chen
doaj   +1 more source

Enzymatic functionalization of carbon-hydrogen bonds [PDF]

, 2011
The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds continues to progress at a rapid pace due to the significant economic and environmental benefits of these transformations over traditional synthetic methods.
Arnold, Frances H., Coelho, Pedro S., Lewis, Jared C.   +2 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source