Results 131 to 140 of about 220,248 (385)

Use of Non-Steroidal Anti-Inflammatory Drugs That Elevate Cardiovascular Risk: An Examination of Sales and Essential Medicines Lists in Low-, Middle-, and High-Income Countries [PDF]

, 2013
PMCID: PMC3570554This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Dans, A Rostom, CP Cannon, D Henry, David Henry, E Masso Gonzalez, EL Fosbol, Fiona Mary Turnbull, JJ Deeks, JM Scheiman, L Garcia Rodriguez, P Kearney, P McGettigan, P McGettigan, Patricia McGettigan, S Hernandez-Dıaz, S Singh, S Trelle, SL Collins, T Grosser, V Strand   +20 more
core   +3 more sources

Identification of a l‐Threonine‐Utilizing Hydrazine Synthetase for Thrazarine Biosynthesis in Streptomyces coerulescens MH802‐fF5

ChemBioChem, EarlyView.
A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai, Hideyuki Muramatsu, Masayuki Igarashi, Yohei Katsuyama, Yasuo Ohnishi   +4 more
wiley   +1 more source

Comparative genomic analyses reveal a lack of a substantial signature of host adaptation in Rhodococcus equi (‘Prescottella equi’) [PDF]

, 2013
Rhodococcus equi (‘Prescottella equi’) is a pathogenic actinomycete primarily infecting horses but has emerged as an opportunistic human pathogen. We have sequenced the genome of the type strain of this species, R.
Arruda, Aziz, Aziz, Clark, Darling, Giguere, Goodfellow, Grant, Jones, Jones, Jones, Kedlaya, Kämpfer, Lai, Law, Letek, Letek, Lowder, McLeod, Mohn, Pena-Moctezuma, Prescott, Prescott, Resch, Reumerman, Sangal, Sangal, Segata, Sekine, Takai, Takai, Teufel, Vazquez-Boland, Vera-Cabrera, Vernikos, Yamshchikov   +35 more
core   +1 more source

Biomimetic chloroplasts: Two‐phase microfluidic platforms with selective permeability for artificial photosynthesis

Droplet, EarlyView.
We present a biomimetic chloroplast system that integrates light‐dependent and light‐independent reactions, reaction compartments, and selectively permeable interfaces using a biphasic microfluidic droplet platform. This system enables continuous substrate–product exchange, mitigating product inhibition and side reactions, thus enhancing reaction ...
Guanxiong Wang, Meiying Hong, Chonghui Yang, Menghan Yang, Gaozhen Zhao, Haixia Liu, Rui Shen, Siping Wang, Xuming Zhang, Xiaowen Huang, Yaolei Wang   +10 more
wiley   +1 more source

Cytokine Expression of Microscopic Colitis Including Interleukin-17

Gut and Liver, 2015
Background/AimsMicroscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination.
doaj   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.

Brain : a journal of neurology, 2014
The chemokine fractalkine modulates microglial responses in neurodegenerative diseases, including tauopathies, but the mechanistic processes and their relevance in human brain pathologies is not yet known.
I. Lastres-Becker, Nadia G. Innamorato, T. Jaworski, A. Rábano, S. Kügler, F. van Leuven, A. Cuadrado   +6 more
semanticscholar   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Variable Coordination of Peroxide in a Dinuclear Copper Mono‐Oxygenase Model Complex Supported by a Pyridazine‐Bridged Ligand

European Journal of Inorganic Chemistry, EarlyView.
Variable coordination of peroxide: The reaction of the Cu(I) complex‐based on the BPMPD ligand with O2 at low temperatures initially led to a μ‐1,2 peroxo species (Cu2O2). By addition of an acid (lutidinium triflate), this species can be reversibly converted into a μ‐1,1‐hydroperoxo complex, which is monitored using UV/Vis spectroscopy and X‐ray ...
Alexander Stüber, Ramona Jurgeleit, Kira Berger, Benjamin Grimm‐Lebsanft, Sören Buchenau, Laura Senft, Christian Näther, Ivana Ivanović‐Burmazović, Michael Rübhausen, Maria A. Naumova, Felix Tuczek   +10 more
wiley   +1 more source