Results 1 to 10 of about 13,927 (251)

Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases

Engineering Microbiology, 2023
Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze the oxidative modification of various molecules, from DNA, RNA, and proteins to primary and secondary metabolites.
Ikuro Abe, Hui Tao
exaly   +3 more sources

Structural and functional characterization of dihydrodiol dehydrogenase PahB recognizing high-molecular-weight PAH substrates [PDF]

Applied and Environmental Microbiology
Polycyclic aromatic hydrocarbons (PAHs), especially high-molecular-weight PAHs (HMW-PAHs), are persistent environmental pollutants that are difficult to remove and challenge environmental management. Altererythrobacter sp.
Qun Han, Lin-Lin Tian, Lu Guo, Rui Cui, Ze-Shen Liu, De-Feng Li   +5 more
doaj   +2 more sources

Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase [PDF]

Nature Communications
Protein-hydroxylation catalysed by Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases is an important regulatory mechanism in human biology. Such oxygenases typically coordinate their Fe(II) cofactor via a conserved triad of an aspartate- or glutamate-
Mariska de Munnik, Amelia Brasnett, Tiankun Zhou, William Myers, Yicheng Wang, Kuntal Chatterjee, Anthony Tumber, Stephen A. Marshall, Philipp S. Simon, Pierre Aller, Anastasiia Shilova, Danny Axford, Hiroki Makita, Daniel W. Paley, Vandana Tiwari, Alexander T. Stead, Sebastian Dehe, Humberto Sanchez, Daniel J. Rosenberg, Roberto Alonso-Mori, Asmit Bhowmick, Junko Yano, Vittal K. Yachandra, Jaehyun Park, Sehan Park, Allen M. Orville, Lennart Brewitz, Jan F. Kern, Christopher J. Schofield, Patrick Rabe   +29 more
doaj   +2 more sources

Eicosanoids in inflammation in the blood and the vessel

Frontiers in Pharmacology, 2022
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi, Eliana Botta, Michael Holinstat, Michael Holinstat   +3 more
doaj   +1 more source

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

mSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu, Vipul Solanki, Anil Kumar Pinnaka, Krishan Gopal Thakur   +3 more
doaj   +3 more sources

Characterization and Function Analysis of the Beta-Carotene Oxygenase-like Genes in Carotenoids Metabolism of the Ridgetail White Prawn Exopalaemon carinicauda

Frontiers in Physiology, 2020
Carotenoids are almost universally distributed in living organisms. The oxidative metabolism by carotene oxygenase contributes to the metabolic processes of carotenoids.
Yue Jin, Yue Jin, Yue Jin, Yang Yu, Yang Yu, Yang Yu, Chengsong Zhang, Chengsong Zhang, Chengsong Zhang, Shihao Li, Shihao Li, Shihao Li, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Fuhua Li, Fuhua Li, Fuhua Li, Fuhua Li   +18 more
doaj   +1 more source

Identification of Disease-Related 2-Oxoglutarate/Fe (II)-Dependent Oxygenase Based on Reduced Amino Acid Cluster Strategy

Frontiers in Cell and Developmental Biology, 2021
The 2-oxoglutarate/Fe (II)-dependent (2OG) oxygenase superfamily is mainly responsible for protein modification, nucleic acid repair and/or modification, and fatty acid metabolism and plays important roles in cancer, cardiovascular disease, and other ...
Jian Zhou, Suling Bo, Hao Wang, Lei Zheng, Pengfei Liang, Yongchun Zuo   +5 more
doaj   +1 more source

Transcriptomic Analysis of Rhodococcus opacus R7 Grown on o-Xylene by RNA-Seq

Frontiers in Microbiology, 2020
Xylenes are considered one of the most common hazardous sources of environmental contamination. The biodegradation of these compounds has been often reported, rarer the ability to oxidize the ortho-isomer.
Jessica Zampolli, Alessandra Di Canito, Andrea Manconi, Luciano Milanesi, Patrizia Di Gennaro, Alessandro Orro   +5 more
doaj   +1 more source

The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines

Synthetic and Systems Biotechnology, 2018
Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities. Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways.
Keqiang Fan, Qian Zhang
doaj   +1 more source

Enzyme Kinetics of Organic Contaminant Oxygenations

CHIMIA, 2020
Enzymatic oxygenations initiate biodegradation processes of many organic soil and water contaminants. Even though many biochemical aspects of oxygenation reactions are well-known, quantifying rates of oxidative contaminant removal as well as the extent ...
Charlotte E. Bopp, Hans-Peter E. Kohler, Thomas B. Hofstetter   +2 more
doaj   +1 more source