Results 1 to 10 of about 13,613 (257)
Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases
Engineering Microbiology, 2023 Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze the oxidative modification of various molecules, from DNA, RNA, and proteins to primary and secondary metabolites.
Ikurô Abe, Hui Tao
exaly +3 more sources
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase [PDF]
Nature CommunicationsProtein-hydroxylation catalysed by Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases is an important regulatory mechanism in human biology. Such oxygenases typically coordinate their Fe(II) cofactor via a conserved triad of an aspartate- or glutamate-
Mariska de Munnik +29 more
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Eicosanoids in inflammation in the blood and the vessel
Frontiers in Pharmacology, 2022 Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi +3 more
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Heme oxygenase-like dimetal oxidases and oxygenases. [PDF]
Biochem Soc TransAbstract The first heme oxygenase-like dimetal oxidase/oxygenase (HDO) was functionally validated through coordinated spectroscopic and rapid kinetic studies of the fatty acid decarboxylase UndA. The enzyme superfamily has since been recognized to orchestrate a variety of substrate transformations for natural product biosynthesis.
Skirboll SS, Ledinina AE, Makris TM.
europepmc +2 more sources
Applied Microbiology and Biotechnology, 2018 Natural rubber (NR), poly(cis-1,4-isoprene), is used in an industrial scale for more than 100 years. Most of the NR-derived materials are released to the environment as waste or by abrasion of small particles from our tires. Furthermore, compounds with isoprene units in their molecular structures are part of many biomolecules such as terpenoids and ...
Dieter Jendrossek, Jakob Birke
openaire +2 more sources
mSystems, 2019 The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu +3 more
doaj +3 more sources
Frontiers in Physiology, 2020 Carotenoids are almost universally distributed in living organisms. The oxidative metabolism by carotene oxygenase contributes to the metabolic processes of carotenoids.
Yue Jin +18 more
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Frontiers in Cell and Developmental Biology, 2021 The 2-oxoglutarate/Fe (II)-dependent (2OG) oxygenase superfamily is mainly responsible for protein modification, nucleic acid repair and/or modification, and fatty acid metabolism and plays important roles in cancer, cardiovascular disease, and other ...
Jian Zhou +5 more
doaj +1 more source
Transcriptomic Analysis of Rhodococcus opacus R7 Grown on o-Xylene by RNA-Seq
Frontiers in Microbiology, 2020 Xylenes are considered one of the most common hazardous sources of environmental contamination. The biodegradation of these compounds has been often reported, rarer the ability to oxidize the ortho-isomer.
Jessica Zampolli +5 more
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Synthetic and Systems Biotechnology, 2018 Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities. Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways.
Keqiang Fan, Qian Zhang
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