Results 31 to 40 of about 60,708 (241)

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources

Heme oxygenase-1: emerging target of cancer therapy

Journal of Biomedical Sciences, 2015
Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells.
L. Chau
semanticscholar   +1 more source

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

Angewandte Chemie, EarlyView.
A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang, Ying Huang, Raed Nachawati, Philipp Huber, Grit Walther, Lucas Gregor, Ivan Vilotijević, Pierre Stallforth   +7 more
wiley   +2 more sources

Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota

Angewandte Chemie, EarlyView.
Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that ...
Elena Herzog, Keishi Ishida, Kirstin Scherlach, Xiuqiang Chen, Benjamin Bartels, Sarah P. Niehs, Bachar Cheaib, Gianni Panagiotou, Christian Hertweck   +8 more
wiley   +2 more sources

Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2

BMC Complementary and Alternative Medicine, 2011
Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ...
Hori Osamu, Hashida Koji, Döring Frank, Schmelzer Constance, Schrader Charlotte, Breckwoldt Dorothea, Boesch-Saadatmandi Christine, Wagner Anika E, Matsugo Seiichi, Rimbach Gerald   +9 more
doaj   +1 more source

Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene*

Journal of Biological Chemistry, 1999
Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1) gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf, and Cap’n’Collar/basic leucine zipper (CNC-bZIP) families of proteins. In
J. Alam, D. Stewart, Cheri L. Touchard, Sujji Boinapally, A. Choi, J. Cook   +5 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Oxygen Doping Enables Tailored Built‐In Electric Fields in FeOCl/g‐C3N4 Heterojunctions for Enhanced Peroxymonosulfate Activation

Advanced Functional Materials, EarlyView.
Oxygen‐doping modulated g‐C3N4 support enables a strong built‐in electric field (BIEF) in FeOCl‐OCN.This enhanced BIEF induces the rearrangement of Fe(II)/Fe(III) in FeOCl, which subtly improves intermediates adsorption and also reduces the energy barrier of *O production, thereby achieving efficient PMS activation with 1O2 and Fe(IV)= O as the primary
Ying Zeng, Hong Qin, Fuqi Wu, Jing Gao, Wenyang Li, Jiaqi Li, Shengyi Wu, Piao Xu, Cui Lai, Ziwei Wang   +9 more
wiley   +1 more source

DOWNY MILDEW RESISTANT 6 and DMR6-LIKE OXYGENASE 1 are partially redundant but distinct suppressors of immunity in Arabidopsis.

The Plant Journal, 2015
Arabidopsis downy mildew resistant 6 (dmr6) mutants have lost their susceptibility to the downy mildew Hyaloperonospora arabidopsidis. Here we show that dmr6 is also resistant to the bacterium Pseudomonas syringae and the oomycete Phytophthora capsici ...
T. Zeilmaker, Nora R. Ludwig, Joyce Elberse, Michael F. Seidl, L. Berke, A. van Doorn, R. Schuurink, B. Snel, G. van den Ackerveken   +8 more
semanticscholar   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source