Results 91 to 100 of about 13,374 (242)

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, EarlyView.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

Genome wide analysis of carotenoid cleavage oxygenases (CCO) gene family in Arachis hypogaea (peanut) under biotic stress

BMC Genomics
Carotenoid cleavage oxygenases (CCOs) enzymes play a vital role in plant growth and development through the synthesis of apocarotenoids and their derivative.
Arsalan Ahmad, Adnan Sami, Umer Habib, Muhammad Ali, Muhammad Shafiq, Muhammad Zeshan Haider, Shahbaz Ahmad, Baber Ali, Steve Harakeh, Rania M. Makki, Talha Chaudhary, Fathia A. Soudy   +11 more
doaj   +1 more source

Intravenous paracetamol does not have significant opioid‐sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery

Veterinary Record, EarlyView.
Abstract Background Data evaluating paracetamol combined with NSAIDs in dogs are scarce. Results of clinical studies in dogs investigating intravenous paracetamol vary. Methods Dogs were randomised to either receive 10 mg/kg paracetamol intravenously after induction of anaesthesia and every 8 hours during hospitalisation (test) or not (control).
Robin Stallard, Julia Deutsch, Joanna Murrell   +2 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Response of Fecal Bacteria and Fungi to Tannin‐Rich Diets in Sika Deer (Cervus nippon): Evidence from Both Feeding Experiments and Field Investigations

Integrative Zoology, EarlyView.
Feeding with tannin‐rich diets altered the fecal microbial composition and increased the relative abundance of tannin‐degrading microbes. We hypothesize that fecal bacteria and fungi may play important roles in helping herbivores adapt to tannin‐rich diets but respond to different tannin concentrations varies.
Di Zhu, Feng Wu, Peiying Wen, Haiyang Gao, Xiaoran Hao, Hongfang Wang   +5 more
wiley   +1 more source

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is an aggressive disease with poor survival and high relapse rates. Coupled with the complex mutational burden observed, there is an unmet clinical need for more targeted therapies. Epigenetic therapies have shown promise both as monotherapy and in combination strategies and specifically histone lysine demethylase,
Laura Monaghan, Roderick P. Bunschoten, Joana Bittencourt‐Silvestre, Taeju Park, Susan Gannon, Petrisor Alin Pirvan, Alex Hoose, Helen Wheadon, Robert M. J. Liskamp, Xu Huang, Heather G. Jørgensen   +10 more
wiley   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source