Results 291 to 300 of about 82,259 (373)

Protective Effect and Mechanism of Rosiglitazone in α‐amanitin‐induced Hepatotoxicity Via Activation of PPAR‐γ/Nrf2 Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 2, February 2026.
ABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Fuping Lai, Ya Liao, Jin Wu, Tinggang Wang, Guiyi Zhang, Xiaojun Zhang, Caiyun Xia, Jie Hu, Yuanlan Lu   +8 more
wiley   +1 more source

Anticancer Secondary Metabolites Produced by Fungi: Potential and Representative Compounds. [PDF]

Int J Mol Sci
García-Estrada C, Barreiro C, Martín JF.   +2 more
europepmc   +1 more source

Heme-Dependent Rubber Oxygenase RoxA ofXanthomonassp. Cleaves the Carbon Backbone of Poly(cis-1,4-Isoprene) by a Dioxygenase Mechanism

, 2005
Reinhard Braaz, Wolfgang Armbruster, Dieter Jendrossek   +2 more
openalex   +1 more source

High‐Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Richard L. Vath, Samuel B. Fernandes, Brandon Monier, Katarzyna Głowacka, Julia Walter, Alexander E. Lipka, John Ferguson, Carl J. Bernacchi, Taylor Pederson, Johannes Kromdijk   +9 more
wiley   +1 more source

The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response in <i>Fusarium graminearum</i>. [PDF]

Virulence
Luo Z, Mao X, Peng M, Huang C, Liang J, Xiao Y, Abubakar YS, Zheng W, Xiong Y, Wang Z, Chen M, Zheng H.   +11 more
europepmc   +1 more source

Cryo‐EM reveals an ensemble of cytochrome P450 reductase conformations in solution

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The eukaryotic electron transport system, mediated by cytochrome P450 reductase (CPR), plays a crucial role in driving myriads of reactions involved in the biosynthesis of physiologically active compounds (such as sterols, steroids, vitamins, and natural products), as well as in the metabolism of drugs, toxins, and carcinogens.
Galina I. Lepesheva, Tatiana Y. Hargrove, Yi Ren   +2 more
wiley   +1 more source

Astaxanthin Overproduction Enhanced by Metabolomics-Guided Rational Metabolic Engineering in <i>Synechococcus</i> sp. PCC 7002. [PDF]

ACS Synth Biol
Ida K, Tanaka K, Kato Y, Koike N, Horie Y, Matsuda M, Yasueda H, Kondo A, Hasunuma T.   +8 more
europepmc   +1 more source

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real‐World Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Ahenk Zeynep Sayin, Lars Kuepfer
wiley   +1 more source

BTG13-related metalloenzymes: Atypical non-heme iron-dependent dioxygenases with unusual coordination patterns and catalytic mechanisms. [PDF]

Eng Microbiol
Deng Z, Yuan Z, Luo Z, Rao Y.
europepmc   +1 more source

The Expression of Heme Oxygenase-1 in Human-Derived Cancer Cell Lines

, 2011
Parisa Bahmani, Golamhossein Hassanshahi, Raheleh Halabian, Amaneh Mohammadi Roushandeh, Ali Jahanian‐Najafabadi, Mehryar Habibi Roudkenar   +5 more
openalex   +1 more source