Results 61 to 70 of about 38,938 (333)
Advanced Healthcare Materials, EarlyView.Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi +26 more
wiley +1 more source
Synthetic and Systems Biotechnology, 2018 Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities. Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways.
Keqiang Fan, Qian Zhang
doaj
Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases
Beilstein Journal of Organic Chemistry, 2011 The enzymatic synthesis of tertiary alcohols by the stereospecific oxidation of tertiary alkyl centers is a most-straightforward but challenging approach, since these positions are sterically hindered.
Christian Klein, Wolfgang Hüttel
doaj +1 more source
First Record of \u3ci\u3eAphis Helianthi\u3c/i\u3e (Homoptera: Aphididae) as a Pest of Celery [PDF]
, 2017 In 1989, the aphid Aphis helianthi severely damaged five of 10 scouted celery fields in west central Michigan. In 1990 and in 1991, A. helianthi again was a problem. reaching pestiferous levels in three of 10 and two of 10 scouted fields.
Davis, M. G. Kortier, Grafius, E.
core +2 more sources
Understanding miR‐200c: an Important Player in Resistance to Cancer Treatment
Advanced Therapeutics, EarlyView.How can one microRNA alter cancer's response to therapy? miR‐200c plays a central role in therapeutic resistance by modulating epithelial‐mesenchymal transition, apoptosis, cancer stemness features, and drug efflux. This review outlines the context‐dependent functions of miR‐200c in various cancers and highlights its potential as both a biomarker and a
Fatma Sanli, Omer Faruk Karatas
wiley +1 more source
Loss of NR2F6 Protects from Salmonella Typhimurium Infection
Advanced Science, EarlyView.Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk +8 more
wiley +1 more source
Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases
Engineering Microbiology, 2023 Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze the oxidative modification of various molecules, from DNA, RNA, and proteins to primary and secondary metabolites.
Hui Tao, Ikuro Abe
doaj
Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells [PDF]
Endocrinology and Metabolism, 2014 BackgroundReperfusion in ischemia is believed to generate cytotoxic oxidative stress, which mediates reperfusion injury. These stress conditions can initiate lipid peroxidation and damage to proteins, as well as promote DNA strand breaks.
Seung-Jun Yoo +3 more
doaj +1 more source
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA [PDF]
, 2011 Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive.
Falnes, P. O. +10 more
core +1 more source
Advanced Science, EarlyView.This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang +8 more
wiley +1 more source