Results 71 to 80 of about 38,610 (331)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases

Beilstein Journal of Organic Chemistry, 2011
The enzymatic synthesis of tertiary alcohols by the stereospecific oxidation of tertiary alkyl centers is a most-straightforward but challenging approach, since these positions are sterically hindered.
Christian Klein, Wolfgang Hüttel
doaj   +1 more source

Rekombination hybrider Megasynthasen als Schlüssel für die Evolution metabolischer Diversität in Cyanobakterien

Angewandte Chemie, EarlyView.
Natürliche Kombinatorik: Die evolutionäre Rekombination und Anpassung von drei cyanobakteriellen Biosynthese‐Genclustern führte zur Entstehung von Minutumamiden, einer neuen Familie von Peptid‐Polyketid‐Hybriden. Mittels retro‐evolutionärer Analyse gelang die Entdeckung des Nostopeptolids KVJ3, einem evolutionären Vorfahren, der die Biosynthese von ...
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni [PDF]

, 2005
Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the ...
Altschul SF, Anne E Lockyer, Brown DJ, Catherine S Jones, Chang GWM, Chaty S, David Rollinson, Gough J, Leslie R Noble, Lockyer AE, Madera M, Nelson DR, Nelson DR, Omura T, Sambrook J, Snyder MJ, Snyder MJ, Teunissen Y   +17 more
core   +5 more sources

Engineering von Transmembran‐Alkan‐Monooxygenasen zur Verbesserung des Schlüsselschritts in der Biosynthese des Polymervorläufers Tulipalin A

Angewandte Chemie, EarlyView.
Ein Biosyntheseweg für den Polymervorläufer Tulipalin A ausgehend von Isoprenylacetat wird hier präsentiert. Die Alkan‐Monooxygenase AlkB katalysiert die chemo‐ und regioselektive terminale Hydroxylierung von Isoprenylacetat und die Aktivität konnte durch rationelles Engineering des Membranenzyms weiter gesteigert werden. Die vollständige Oxidation zur
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. [PDF]

PLoS ONE, 2015
Oxidative stress has been known to be involved in pathogenesis of dry eye disease. However, few studies have comprehensively investigated the relationship between hyperosmolarity and oxidative damage in human ocular surface.
Ruzhi Deng, Xia Hua, Jin Li, Wei Chi, Zongduan Zhang, Fan Lu, Lili Zhang, Stephen C Pflugfelder, De-Quan Li   +8 more
doaj   +1 more source

Derivation of the formyl-group oxygen of chlorophyll b from molecular oxygen in greening leaves of a higher plant (Zea mays) [PDF]

, 1993
Using mass spectroscopy, we demonstrate as much as 93% enrichment of the 7-formyl group oxygen of chlorophyll b when dark-grown, etiolated maize leaves are greened under white light in the presence of 18O2. This suggests that a mono-oxygenase is involved
Beale, Björkman, Chunaev, E. Cmiel, H. Scheer, Hennigsen, Ingrid Katheder, Klein, Nashrulhaq-Boyce, Naylor, Porra, R.J. Porra, Rüdiger, Sato, Schneegurt, W. Schäfer, Walker   +16 more
core   +1 more source

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA [PDF]

, 2011
Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive.
Falnes, P. O., Kirpekar, F., Klungland, A., Krokan, H. E., Leihne, V., Leszczynska, G., Lien, G. F., Malkiewicz, A., Songe-Moller, L., Vagbo, C. B., van den Born, E.   +10 more
core   +1 more source

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).

PLoS ONE, 2011
Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules.
Armin Thalhammer, Zuzana Bencokova, Rachel Poole, Christoph Loenarz, Julie Adam, Linda O'Flaherty, Johannes Schödel, David Mole, Konstantinos Giaslakiotis, Christopher J Schofield, Ester M Hammond, Peter J Ratcliffe, Patrick J Pollard   +12 more
doaj   +1 more source

Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]

PLoS ONE, 2011
In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves, Elaine S Costa, Marcos H F Sorgine, Maria Clara L Nascimento-Silva, Cristina Teodosio, Paloma Bárcena, Hugo C Castro-Faria-Neto, Patrícia T Bozza, Alberto Orfao, Pedro L Oliveira, Clarissa M Maya-Monteiro   +10 more
doaj   +1 more source