Results 41 to 50 of about 2,903,234 (253)

Breath-Holding as a Stimulus to Assess Peripheral Oxygenation Flow Using Near-Infrared Spectroscopic Imaging

Bioengineering
A mammalian breath-hold (BH) mechanism can induce vasoconstriction in the limbs, altering blood flow and oxygenation flow changes in a wound site. Our objective was to utilize a BH paradigm as a stimulus to induce peripheral tissue oxygenation changes ...
Kevin Leiva, Isabella Gonzalez, Juan Murillo, Aliette Espinosa, Robert S. Kirsner, Anuradha Godavarty   +5 more
doaj   +1 more source

Acute and Chronic Effects of SGLT2 Inhibitor Empagliflozin on Renal Oxygenation and Blood Pressure Control in Nondiabetic Normotensive Subjects: A Randomized, Placebo‐Controlled Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The sodium/glucose cotransporter 2 inhibitor empagliflozin has cardiorenal protective properties through mechanisms beyond glucose control. In this study we assessed whether empagliflozin modifies renal oxygenation as a possible mechanism of ...
Anne Zanchi, Michel Burnier, Marie‐Eve Muller, Arlène Ghajarzadeh‐Wurzner, Marc Maillard, Nicolas Loncle, Bastien Milani, Nathalie Dufour, Olivier Bonny, Menno Pruijm   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

eLife, 2020
Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al ...
Christian Damsgaard, Henrik Lauridsen, Till S Harter, Garfield T Kwan, Jesper S Thomsen, Anette MD Funder, Claudiu T Supuran, Martin Tresguerres, Philip GD Matthews, Colin J Brauner   +9 more
doaj   +1 more source

The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation [PDF]

British Journal of Cancer, 1995
Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified experimentally. This study was performed to explore changes in tumour oxygenation induced by treatment with normobaric and hyperbaric oxygen and carbogen.
D M, Brizel, S, Lin, J L, Johnson, J, Brooks, M W, Dewhirst, C A, Piantadosi   +5 more
openaire   +2 more sources

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Dapagliflozin Mitigates Medullary Hypoxia in CKD Patients

Kidney360
Key Points. Dapagliflozin significantly improves renal medullary oxygenation in CKD, constituting a potential mechanism of its nephroprotection. The enhancement of medullary oxygenation is more pronounced in nondiabetic patients, suggesting a distinct ...
Elisa Russo, Emilio Venturelli, Julie Di Vincenzo, Lucia Macciò, Pasquale Esposito, Francesca Cappadona, Giulio Ferrazzi, Rocco Grillo, Maria Beatrice Damasio, Giacomo Garibotto, Francesca Viazzi   +10 more
doaj   +1 more source

Anoxygenic photosynthesis and the delayed oxygenation of Earth’s atmosphere

Nature Communications, 2019
Competition dynamics between early Earth photosynthetic microorganisms are unclear. Here, the authors demonstrate that competition for light and nutrients between oxygenic phototrophs and Fe-based photosynthesizers in surface oceans provides a novel ...
Kazumi Ozaki, Katharine J. Thompson, Rachel L. Simister, Sean A. Crowe, Christopher T. Reinhard   +4 more
doaj   +1 more source

COVID-19: A Possible Contribution of the MAPK Pathway

Biomedicines, 2023
Background: COVID-19 is characterized by an uncontrolled inflammatory response with high pro-inflammatory cytokine production through the activation of intracellular pathways, such as mitogen-activated protein kinase (MAPK).
Jessica Cusato, Alessandra Manca, Alice Palermiti, Jacopo Mula, Martina Costanzo, Miriam Antonucci, Mattia Trunfio, Silvia Corcione, Francesco Chiara, Elisa Delia De Vivo, Alice Ianniello, Micol Ferrara, Giovanni Di Perri, Francesco Giuseppe De Rosa, Antonio D’Avolio, Andrea Calcagno   +15 more
doaj   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source