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Biological activities of oxysterols
Free Radical Biology and Medicine, 1989Literature dealing with the biological activities of cholesterol autoxidation products and related oxysterols in vivo and in vitro published since the previous 1981 monograph is reviewed. Although several oxysterols are important cholesterol metabolites implicated in bile acids and steroid hormones biosynthesis, effects on cellular membranes and on ...
L L, Smith, B H, Johnson
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Oxysterols and nuclear receptors
Molecular and Cellular Endocrinology, 2019Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X receptors. Oxysterols are also known to be ligands for the RAR-related orphan receptors, involved in normal T cell differentiation.
Liqian Ma, Erik R. Nelson
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2010
In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
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In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
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Biochimie, 2013
I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work. The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile acid precursor.
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I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work. The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile acid precursor.
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Oxysterols increase in diabetic rats
Free Radical Research, 2005To address whether diabetes enhances lipid peroxidation and attenuates nitric oxide (NO) generation resulting in tissue complications, we measured oxysterols and NO metabolites (NOx) in the tissues of diabetic Wistar rats. After 4 weeks of streptozotocin injection (STZ, 80 mg/kg, i.p.), we measured 7 alpha- and 7 beta-hydroperoxycholest-5-en-3 beta-ol (
Naoki, Yoshioka +3 more
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Oxysterols and Alcoholic Liver Disease
Alcoholism: Clinical and Experimental Research, 1990A new theory is presented implicating oxidative cholesterol metabolism and oxysterols as possible factors in the development of alcoholic liver disease. Our present studies have revealed the accumulation of cholesta‐3,5‐dien‐7‐one, 13.05 ± 2.75 μg/g (n = 8), and cholesta‐4,6‐dien‐3‐one, 2.26 ± 0.88 μg/g (n = 8) in fatty alcoholic liver, as compared ...
M T, Ryzlak +3 more
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Oxysterols in bile acid metabolism
Clinica Chimica Acta, 2011Increasing body of evidence is available indicating that oxysterols are more much than intermediates of metabolic pathways. Oxysterols play a role in the regulation of cholesterol synthesis, transport and efflux. A scavenger effect of cholesterol 27-hydroxylase on elevated serum cholesterol levels is well demonstrated.
Crosignani, A +3 more
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Oxysterols: Old Tale, New Twists
Annual Review of Pharmacology and Toxicology, 2016Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional mechanisms for controlling cholesterol levels. However, they are increasingly associated with a wide variety of other, sometimes surprising cell functions.
Winnie, Luu +4 more
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Oxysterols suppress constitutive fibrinogen expression
Thrombosis and Haemostasis, 2003SummaryElevated levels of both fibrinogen and cholesterol are risk factors in coronary artery disease. Previously we reported a metabolic link between fibrinogen and lipid metabolism in that HepG2 cells that were programmed by transfection of Bβ-fibrinogen cDNA to overexpress fibrinogen exhibited increased synthesis of cholesterol and increased ...
Hui, Xia, Colvin M, Redman
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1987
Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
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Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
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