Results 161 to 170 of about 10,561 (173)
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Mechanisms of oxysterol-induced apoptosis
Current Opinion in Lipidology, 2001The rationale for the present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis. This perspective is based on studies that show that induction of apoptosis in vascular cells is an important process in atherogenesis, that apoptosis can be induced by oxLDL, and that the oxysterol component of oxLDL is responsible for ...
Panini, S. R., Sinensky, M. S.
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A proteolytic fragment of the oxysterol receptor which retains oxysterol binding activity
Archives of Biochemistry and Biophysics, 1991The structural organization of the oxysterol receptor, postulated to be involved in the regulation of 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol biosynthesis in mammalian cells, has been explored by limited proteolysis with trypsin, alpha-chymotrypsin, and endoproteinase GluC.
Taylor, F R, Shown, E P, Kandutsch, A A
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Oxysterols: Genesis and basic functions
Russian Journal of Bioorganic Chemistry, 2007The structural peculiarities of the most widespread oxysterols, the products of oxidative transformations of cholesterol are discussed. The transformations proceed with the participation of enzymatic systems of the body or as a result of various nonenzymatic reactions. The pathways of their formation from cholesterol are also considered.
A V, Antonchik +2 more
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Connective tissue responses to oxysterols
Atherosclerosis, 1982We studied the effect of sterols and oxidized sterols on promoting tissue inflammation and necrosis, and on causing cell death in tissue culture. The cells studied were mouse fibroblasts and macrophages, and pig vascular smooth muscle. The lipid preparations were dibromide-purified cholesterol, air-oxidized cholesterol, 25-hydroxycholesterol ...
A, Baranowski +3 more
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2000
Abstract Cholesterol oxidation products, or oxysterols, are derivatives of cholesterol that have been modified by addition of one or more oxygen functional groups (Table 17.1, Fig. 17.1). Ever since they were first discovered in atherosclerotic lesions more than 50 years ago, controversy has surrounded their role in atherosclerosis.
Malcolm A Lyons, Andrew J Brown
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Abstract Cholesterol oxidation products, or oxysterols, are derivatives of cholesterol that have been modified by addition of one or more oxygen functional groups (Table 17.1, Fig. 17.1). Ever since they were first discovered in atherosclerotic lesions more than 50 years ago, controversy has surrounded their role in atherosclerosis.
Malcolm A Lyons, Andrew J Brown
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Oxysterols and Oxysterol-Binding Proteins in Cellular Lipid Metabolism
2009Oxysterols are 27-carbon oxidized derivatives of cholesterol or by-products of cholesterol synthesis with multiple biological activities. The major oxysterols arise either via cholesterol oxidation by cytochrome P450 enzymes or via non-enzymatic autoxidation processes. Oxysterols are present in healthy tissues or plasma at very low levels but are found
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