Results 21 to 30 of about 10,561 (173)

Determination of Pharmaceuticals, Heavy Metals, and Oxysterols in Fish Muscle

Molecules, 2021
The present study aimed to assess the levels of 98 multi-class pharmaceuticals including cardiovascular drugs, antidepressants, hypnotics, antibiotics, and sulfonamides occurring in the muscle tissue of fish caught in the Baltic Sea.
Barbara Bobrowska-Korczak, Agnieszka Stawarska, Arkadiusz Szterk, Karol Ofiara, Małgorzata Czerwonka, Joanna Giebułtowicz   +5 more
doaj   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes. [PDF]

Adv Sci (Weinh)
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Asare-Bediako B, Calzi SL, Behnsen JG, Prasad R, Blaszkiewicz M, Adu-Rutledge Y, Rosencrans RF, Floyd JL, Rennhack A, Stanford D, Lin A, Lydic TA, Sheridan CM, Boulton ME, Townsend KL, Busik JV, Grant MB.   +16 more
europepmc   +2 more sources

7-Ketocholesterol Promotes Oxiapoptophagy in Bone Marrow Mesenchymal Stem Cell from Patients with Acute Myeloid Leukemia

Cells, 2019
7-Ketocholesterol (7-KC) is a cholesterol oxidation product with several biological functions. 7-KC has the capacity to cause cell death depending on the concentration and specific cell type.
Jessica Liliane Paz, Debora Levy, Beatriz Araujo Oliveira, Thatiana Correia de Melo, Fabio Alessandro de Freitas, Cadiele Oliana Reichert, Alessandro Rodrigues, Juliana Pereira, Sergio Paulo Bydlowski   +8 more
doaj   +1 more source

Metabolic Control of Innate Lymphoid Cell Migration

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues ...
Tim Willinger
doaj   +1 more source

4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor

Journal of Lipid Research, 2021
Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood.
Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian, Daniel S. Ory, Douglas F. Covey, Daniel K. Nomura, Andreas Stahl, Ethan J. Weiss, Roberto Zoncu   +11 more
doaj   +1 more source

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol

Journal of Lipid Research, 2009
Side chain oxysterols are cholesterol derivatives thought to signal the abundance of cell cholesterol to homeostatic effector proteins. Here, we investigated how plasma membrane (PM) cholesterol might regulate 27-hydroxycholesterol (HC) biosynthesis in ...
Yvonne Lange, Theodore L. Steck, Jin Ye, Michael H. Lanier, Vasumathi Molugu, Daniel Ory   +5 more
doaj   +1 more source

Preparation of Oxysterols by C–H Oxidation of Dibromocholestane with Ru(Bpga) Catalyst

Molecules, 2021
Seven mono- and dihydroxycholesterols were prepared by direct C–H oxidation of the cholestane skeleton with a recently developed Ru(Bpga) catalyst (Ru(Bpga) = [RuCl (bpga) (PPh3)] Cl; bpga = 2-(bis(pyridin-2-ylmethyl)amino)-N-(2,6-dimethylphenyl ...
Yui Fujii, Makoto Yoritate, Kana Makino, Kazunobu Igawa, Daiki Takeda, Daiki Doiuchi, Katsuhiko Tomooka, Tatsuya Uchida, Go Hirai   +8 more
doaj   +1 more source

Macrophages, Oxysterols and Atherosclerosis

Circulation Journal, 2010
Macrophages play central roles in immunity and homeostasis, and contribute to the pathogenesis of atherosclerosis through their accumulation of cholesterol and the production of inflammatory mediators and cytokines. Recent studies indicate that oxysterols influence diverse aspects of macrophage biology.
Norihito, Shibata, Christopher K, Glass
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source