Results 81 to 90 of about 10,561 (173)

Developing an Enzyme-Assisted Derivatization Method for Analysis of C₂₇ Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry

Molecules, 2019
Enzyme-assisted derivatization for sterol analysis (EADSA) is a technology designed to enhance sensitivity and specificity for sterol analysis using electrospray ionization⁻mass spectrometry.
Jonas Abdel-Khalik, Peter J. Crick, Eylan Yutuc, Yuqin Wang, William J. Griffiths   +4 more
doaj   +1 more source

LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
In vitro, low‐density lipoprotein cholesterol (LDL cholesterol) promotes the accumulation of lipid derivatives in astrocytes. Additionally, LDL cholesterol exposure causes a decrease in the expression of low‐density lipoprotein receptor (LDLr), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), and sterol regulatory element‐binding transcription factor ...
Gabriela Joras Baumart, Matheus Scarpatto Rodrigues, Juliete Nathali Sholl, Arieli Cruz de Sousa, Augusto Ferreira Weber, Lílian Corrêa Costa‐Beber, Hémelin Resende Farias, Mariana Viana Costa, Ariadni Mesquita Peres, Pedro Rocha de Camargo, Fernanda Telles Fróes, Rachel Krolow Bast, Andreza Fabro de Bem, Fabrício Figueiró, Fátima T. C. R. Guma, Jade de Oliveira   +15 more
wiley   +1 more source

Liver X receptors as regulators of metabolism

Biomolecular Concepts, 2015
The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways.
Korach-André Marion, Gustafsson Jan-Åke   +1 more
doaj   +1 more source

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol

Journal of Lipid Research, 2015
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback ...
David B. Iaea, Sarah E. Gale, Agata A. Bielska, Kathiresan Krishnan, Hideji Fujiwara, Hui Jiang, Frederick R. Maxfield, Paul H. Schlesinger, Douglas F. Covey, Jean E. Schaffer, Daniel S. Ory   +10 more
doaj   +1 more source

Identification of a novel sulfonated oxysterol, 5-cholesten-3β,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria

Journal of Lipid Research, 2006
This study reports the discovery of a novel sulfonated oxysterol found at high levels in the mitochondria and nuclei of primary rat hepatocytes after overexpression of the gene encoding steroidogenic acute regulatory protein (StarD1).
Shunlin Ren, Phillip Hylemon, Zong-Ping Zhang, Daniel Rodriguez-Agudo, Dalila Marques, Xiaobo Li, Huiping Zhou, Gregorio Gil, William M. Pandak   +8 more
doaj   +1 more source

Oxysterol Mixture in Hypercholesterolemia-Relevant Proportion Causes Oxidative Stress-Dependent Eryptosis

Cellular Physiology and Biochemistry, 2014
Background/Aims: Oxysterol activity on the erythrocyte (RBC) programmed cell death (eryptosis) had not been studied yet. Effects of an oxysterol mixture in hyper-cholesterolemic-relevant proportion, and of individual compounds, were investigated on RBCs ...
Luisa Tesoriere, Alessandro Attanzio, Mario Allegra, Antonio Cilla, Carla Gentile, Maria A. Livrea   +5 more
doaj   +1 more source

Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism[S]

Journal of Lipid Research, 2016
Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions.
Sara Boenzi, Federica Deodato, Roberta Taurisano, Bianca Maria Goffredo, Cristiano Rizzo, Carlo Dionisi-Vici   +5 more
doaj   +1 more source

Oxysterols

Biochemical and Biophysical Research Communications, 2014
William, Griffiths, Hans, Jörnvall
openaire   +4 more sources

Anticancer oxysterols

, 2018
The Integrated Master's Degree in Pharmaceutical Sciences contemplates, in accordance with Directive 2013/55 / EU, the realization of a curricular internship in the area of Community Pharmacy, allowing students to apply in the work context the knowledge aquired throughout the course, as well as gaining new skills.
openaire   +1 more source

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration. [PDF]

Front Mol Neurosci
Ricci RP, Foo CX, Ronacher K, Cullen CL.
europepmc   +1 more source