Results 71 to 80 of about 44,914 (140)

Lipoprotein cholesterol uptake mediates upregulation of bile acid synthesis by increasing cholesterol 7a-hydroxylase but not sterol 27- hydroxylase gene expression in cultured rat hepatocytes.

, 1999
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7α-hydroxylase expression.
Twisk, J.W.R., Wit, E.C.M., Mager, W.H., van der Fits, L.T.E., Post, S.M., Princen, H.M.G., Hoekman, M.F.M.   +6 more
core   +1 more source

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression

, 2001
Fibrates are hypolipidemic drugs that affect the expression of genes involved in lipid metabolism by activating peroxisome proliferator-activated receptors (PPARs).
Staels, B., Gervois, P.P., Post, S.M., Princen, H.M.G., Kuipers, F., Duez, H.   +5 more
core  

Complete Recovery of Oxysterol 7α-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review. [PDF]

J Korean Med Sci, 2018
Hong J, Oh SH, Yoo HW, Nittono H, Kimura A, Kim KM.   +5 more
europepmc   +1 more source

Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity

, 1990
Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous [14C] cholesterol into bile acids was suppressed by addition of bile acids to the ...
Kempen, H.J.M., Voorthuizen, E.M. van, Kwekkeboom, J., Princen, H.M.G.   +3 more
core   +1 more source

HMG-CoA reductase and cholesterol 7-hydroxylase in human liver

, 1984
The activities of HMGCoA reductase and cholesterol 7α-hydroxylase were assayed in liver biopsies of patients with or without cholestyramine treatment.
G. GALLI, E. BOSISIO, G. CIGHETTI, R. TRITAPEPE, M. GALLI KIENLE   +4 more
core   +1 more source

Cholesterol 7α-hydroxylase activity and bile acid synthesis in hepatocytes of unweaned and weaned pigs in monolayer culture

, 1990
Activity of cholesterol 7α-hydroxylase (EC 1.14.13.17) in freshly isolated hepatocytes from unweaned piglets (2 to 3 weeks old) was 16-times lower as compared to hepatocytes from weaned piglets (7 to 8 weeks old).
Kempen, H.J.M., Voorthuizen, E.M. van, Kwekkeboom, J., Princen, H.M.G.   +3 more
core  

Maintenance of bile acid synthesis and cholesterol 7α-hydroxylase activity in cultured rat hepatocytes

, 1990
Addition of foetal-bovine serum to rat hepatocytes cultured in Williams E medium resulted in improved maintenance of bile-acid-synthetic capacity and cholesterol 7α-hydroxylase activity as compared with cultures supplemented with rat or newborn-bovine ...
Meijer, P., Princen, H.M.G.
core   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host-directed therapy. [PDF]

Clin Transl Med
Wang J, Zhou Y, Ji X, Zhao H, Zhan L.
europepmc   +1 more source

Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes

, 1993
We have used primary monolayer cultures of rat hepatocytes to study the effects of physiological concentrations of various bile acids, commonly found in bile of normal rats, on the mechanism of regulation of cholesterol 7α-hydroxylase and bile acid ...
Twisk, J., Princen, H.M.G., Lehmann, E.M.   +2 more
core  

Lipid remodeling in swine spermatozoa: Innovative model for the analysis of oxysterols during capacitation. [PDF]

Vet Anim Sci
Carlo DC, Fabiola E, Ramses BP, Costanza C, Federico F, Luca V, Nicola B, Dario C, Barbara B.   +8 more
europepmc   +1 more source