Results 51 to 60 of about 44,914 (140)

Dysregulated Cholesterol Metabolism and Its Impact on the Tumour Immune Response in Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Colorectal cancer (CRC) ranks among the primary causes of cancer deaths worldwide. Cholesterol metabolism, tightly regulated through biosynthesis, uptake, efflux and conversion, plays a crucial role in CRC development and progression. Dysregulated cholesterol metabolism in cancer cells alters the tumour microenvironment (TME), promoting tumour
Chunyu Zhang, Zhiwei Miao, Yan Xu, Xingchao Zhu, Tongguo Shi   +4 more
wiley   +1 more source

Determination of 25‐Hydroxyvitamin D3 in Rat Brain by Derivatization‐Assisted LC/ESI‐MS/MS

Biomedical Chromatography, Volume 39, Issue 7, July 2025.
ABSTRACT Recent studies have suggested that vitamin D deficiency may have relations with various neuropsychiatric diseases as well as bone diseases. However, the concentrations of vitamin D metabolites in the brain and the relationship between their brain and serum concentrations remain poorly understood.
Toma Shibuya, Fuwari Shishikura, Natsuki Yoshida, Shoujiro Ogawa, Tatsuya Higashi   +4 more
wiley   +1 more source

Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Influence of Dietary and Lifestyle Factors on Gut Microbiota and Cardiovascular Health. ABSTRACT Emerging evidence highlights the pivotal role of gut microbiota in regulating cardiovascular health and disease. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, interacts with its host through metabolites ...
Narendra Kondapalli, Venkatesh Katari, Kesha K. Dalal, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X [PDF]

, 2004
HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.BackgroundLong-term consumption of Western diets can lead to acquired syndrome X, which presents with obesity, insulin resistance, hypertension ...
Roberts, Christian K., Kim, Choong H., Liang, Kaihui, Barnard, R. James, Vaziri, Nosratola D.   +4 more
core   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, Volume 3, Issue 2, Page 131-144, June 2025.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism

Journal of Pharmaceutical Analysis
Intestinal dysbiosis and disrupted bile acid (BA) homeostasis are associated with obesity, but the precise mechanisms remain insufficiently explored.
Chu Zhang, Gui Wang, Xin Yin, Lingshan Gou, Mengyuan Guo, Feng Suo, Tao Zhuang, Zhenya Yuan, Yanan Liu, Maosheng Gu, Ruiqin Yao   +10 more
doaj   +1 more source

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
NPC1L1 Inhibits Osteogenesis via the C/EBPα/Cyp27a1/27‐OHC Axis in Osteoporosis Mechanism: ○NPC1L1 expression decreases during osteogenic differentiation. ○NPC1L1 knockdown enhances osteoblast differentiation, proliferation, and migration. ○NPC1L1 promotes cholesterol metabolism (independent of transport function), elevating Cyp27a1‐dependent 27 ...
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
wiley   +1 more source

Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7α-hydroxylase in rats with subtotal nephrectomy [PDF]

, 1994
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7α-hydroxylase in rats with subtotal nephrectomy. Chronic renal failure is associated with hyperlipidemia and atherosclerosis.
Krieg, Richard J., Vlahcevic, Z. Reno, Pandak, William M., Chan, James C.M., Heuman, D.M., Hanna, James D.   +5 more
core   +1 more source

Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7α-hydroxylase in cultured rat hepatocytes and in vivo in the rat

, 1999
Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents.
Havinga, R., Wit, E.C.M. de, Post, S.M., Paul Zoeteweij, J., Princen, H.M.G., Bos, M.H.A., Kuipers, F.   +6 more
core   +1 more source

The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Briefly, patients with ASCVD have a reduced abundance of B. ovatus in their feces. Oral administration of live B. ovatus attenuated atherosclerosis. Specifically, B. ovatus restores the expression of intestinal barrier proteins and improves bile acid metabolism, while producing the tryptophan metabolite IAA restores the M1/M2 polarisation balance by ...
Wu Liu, Jingyu Wang, Heng Yang, Congcong Li, Wanqi Lan, Tingtao Chen, Yanhua Tang   +6 more
wiley   +1 more source