Results 51 to 60 of about 1,133 (115)

Determination of 25‐Hydroxyvitamin D3 in Rat Brain by Derivatization‐Assisted LC/ESI‐MS/MS

Biomedical Chromatography, Volume 39, Issue 7, July 2025.
ABSTRACT Recent studies have suggested that vitamin D deficiency may have relations with various neuropsychiatric diseases as well as bone diseases. However, the concentrations of vitamin D metabolites in the brain and the relationship between their brain and serum concentrations remain poorly understood.
Toma Shibuya, Fuwari Shishikura, Natsuki Yoshida, Shoujiro Ogawa, Tatsuya Higashi   +4 more
wiley   +1 more source

Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Influence of Dietary and Lifestyle Factors on Gut Microbiota and Cardiovascular Health. ABSTRACT Emerging evidence highlights the pivotal role of gut microbiota in regulating cardiovascular health and disease. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, interacts with its host through metabolites ...
Narendra Kondapalli, Venkatesh Katari, Kesha K. Dalal, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, Volume 3, Issue 2, Page 131-144, June 2025.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
NPC1L1 Inhibits Osteogenesis via the C/EBPα/Cyp27a1/27‐OHC Axis in Osteoporosis Mechanism: ○NPC1L1 expression decreases during osteogenic differentiation. ○NPC1L1 knockdown enhances osteoblast differentiation, proliferation, and migration. ○NPC1L1 promotes cholesterol metabolism (independent of transport function), elevating Cyp27a1‐dependent 27 ...
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
wiley   +1 more source

The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Briefly, patients with ASCVD have a reduced abundance of B. ovatus in their feces. Oral administration of live B. ovatus attenuated atherosclerosis. Specifically, B. ovatus restores the expression of intestinal barrier proteins and improves bile acid metabolism, while producing the tryptophan metabolite IAA restores the M1/M2 polarisation balance by ...
Wu Liu, Jingyu Wang, Heng Yang, Congcong Li, Wanqi Lan, Tingtao Chen, Yanhua Tang   +6 more
wiley   +1 more source

Molecular mechanism of renal lipid accumulation in diabetic kidney disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Diabetic kidney disease (DKD) is a leading cause of end stage renal disease with unmet clinical demands for treatment. Lipids are essential for cell survival; however, renal cells have limited capability to metabolize overloaded lipids. Dyslipidaemia is common in DKD patients and renal ectopic lipid accumulation is associated with disease ...
Zhengying Fang, Ruijie Liu, Jingyuan Xie, John Cijiang He   +3 more
wiley   +1 more source

Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses

Advanced Science, Volume 11, Issue 20, May 28, 2024.
The inflammatory response is a defense mechanism of the innate immune system against infections and other injuries. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. De la Rosa et al. provide evidence that inflammation triggers a reprogramming of the transcription factor
Juan Vladimir de la Rosa, Carlos Tabraue, Zhiqiang Huang, Marta C. Orizaola, Patricia Martin‐Rodríguez, Knut R. Steffensen, Juan Manuel Zapata, Lisardo Boscá, Peter Tontonoz, Susana Alemany, Eckardt Treuter, Antonio Castrillo   +11 more
wiley   +1 more source

Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism

Journal of Pharmaceutical Analysis
Intestinal dysbiosis and disrupted bile acid (BA) homeostasis are associated with obesity, but the precise mechanisms remain insufficiently explored.
Chu Zhang, Gui Wang, Xin Yin, Lingshan Gou, Mengyuan Guo, Feng Suo, Tao Zhuang, Zhenya Yuan, Yanan Liu, Maosheng Gu, Ruiqin Yao   +10 more
doaj   +1 more source

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities

FEBS Open Bio, Volume 14, Issue 2, Page 194-216, February 2024.
The lipid composition of the brain is altered in Alzheimer's disease (AD), and several studies have shown white matter abnormalities and oligodendrocyte dysfunction in AD brains. Therefore, it is speculated that the alteration of brain lipid metabolism is associated with dysfunction of oligodendrocytes and white matter abnormalities in the AD brain ...
Noe Kawade, Koji Yamanaka
wiley   +1 more source

Expression of hepatic genes involved in bile acid metabolism in dairy cows with fatty liver

Journal of Dairy Science
: Bile acids are cholesterol-derived molecules that are primarily produced in the liver. In nonruminants with fatty liver, overproduction of bile acids is associated with liver injury.
Xiliang Du, Mingchao Liu, Erminio Trevisi, Lingxue Ju, Yuting Yang, Wenwen Gao, Yuxiang Song, Lin Lei, Majigsuren Zolzaya, Xinwei Li, Zhiyuan Fang, Guowen Liu   +11 more
doaj   +1 more source