Results 61 to 70 of about 44,914 (140)

Molecular mechanism of renal lipid accumulation in diabetic kidney disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Diabetic kidney disease (DKD) is a leading cause of end stage renal disease with unmet clinical demands for treatment. Lipids are essential for cell survival; however, renal cells have limited capability to metabolize overloaded lipids. Dyslipidaemia is common in DKD patients and renal ectopic lipid accumulation is associated with disease ...
Zhengying Fang, Ruijie Liu, Jingyuan Xie, John Cijiang He   +3 more
wiley   +1 more source

Expression of hepatic genes involved in bile acid metabolism in dairy cows with fatty liver

Journal of Dairy Science
: Bile acids are cholesterol-derived molecules that are primarily produced in the liver. In nonruminants with fatty liver, overproduction of bile acids is associated with liver injury.
Xiliang Du, Mingchao Liu, Erminio Trevisi, Lingxue Ju, Yuting Yang, Wenwen Gao, Yuxiang Song, Lin Lei, Majigsuren Zolzaya, Xinwei Li, Zhiyuan Fang, Guowen Liu   +11 more
doaj   +1 more source

Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses

Advanced Science, Volume 11, Issue 20, May 28, 2024.
The inflammatory response is a defense mechanism of the innate immune system against infections and other injuries. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. De la Rosa et al. provide evidence that inflammation triggers a reprogramming of the transcription factor
Juan Vladimir de la Rosa, Carlos Tabraue, Zhiqiang Huang, Marta C. Orizaola, Patricia Martin‐Rodríguez, Knut R. Steffensen, Juan Manuel Zapata, Lisardo Boscá, Peter Tontonoz, Susana Alemany, Eckardt Treuter, Antonio Castrillo   +11 more
wiley   +1 more source

Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein

, 2004
Oxysterol 7alpha-hydroxylase (CYP7B1) metabolizes oxysterols, potent regulators of lipid homeostasis. Very little is known about transcriptional regulation of human CYP7B1. The present results indicate that sterol response element binding protein (SREBP),
Norlin, Maria,, Chiang, John Y. L.
core   +1 more source

Partial Purification and Characterization of Cholesterol 7α-Hydroxylase from Guinea Pig [PDF]

, 1987
Cholesterol 7α-hydroxylase (cholesterol, NADPH: oxygen oxidoreductase, 7α-xhydroxylating, EC 1.14.13.17), was partially purified from liver microsomes of guinea pig. The purified sample showed a specific activity of 1.
NAKAI, Taketomi
core  

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis [PDF]

, 2019
The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-dihydroxycholesterol, EBI2 mediates migration and differentiation of immune
Schmelczer, G., Spalinger, Marianne R, Lang, Silvia, Frey-Wagner, Isabelle, Mertens, Joachim, Roth, R., Schmelczer, Gérard, Misselwitz, B., Sailer, Andreas W., Mertens, Joachim C., Wyss, A., Klinke, G., Hersberger, Martin; https://orcid.org/, Perkins, N., Ruiz, F., Pabst, Oliver, Pot, C., Hering, Larissa, Atrott, K., Raselli, Tina, Wyss, Annika, Scharl, Michael, Atrott, Kirstin, Lang, S., Spalinger, M.R., Frey-Wagner, I., Hersberger, Martin, Sailer, Andreas, Spalinger, Marianne R., Rogler, Gerhard, Raselli, T., Ruiz, Florian, Rogler, G., Pabst, O., Pot, Caroline, Roth, René, Scharl, M., Mertens, J.C., Klinke, Glynis, Moncsek, Anja, Hersberger, M., Moncsek, A., Misselwitz, Benjamin, Spalinger, Marianne, Rasseli, Tina, Sailer, A.W., Sailer, Andreas W, Perkins, Nathan, Hering, L., Mertens, Joachim C   +49 more
core   +2 more sources

Assay of cholesterol 7α-hydroxylase activity in rat hepatocytes in primary monolayer culture

, 1988
A sensitive and precise method is described to assay cholesterol 7α-hydroxylase activity in homogenates of rat hepatocytes cultured in monolayers for up to 76 h. The assay is based on measurement of the amount of radioactive cholesterol converted into 7α-
Meijer, P., Kempen, H.J.M., Princen, H.M.G., Kwekkeboom, J.   +3 more
core  

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation

, 2018
Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which signals are sensed and what receptors control ILC3 function remain poorly understood.
Parigi, Sara, Eduardo J. Villablanca, Villablanca, Eduardo J, Melo-Gonzalez, Felipe, Hepworth, Matthew; id_orcid, Jacob, Jean-Marie, Paulo Czarnewski, Kvedaraite, Egle, Emgard, Johanna, Samuel Huber, Jean-Marie Jacob, Egle Kvedaraite, Scandella, Elke, Melo Gonzalez, Felipe, Ludewig, Burkhard, Henrique Veiga-Fernandes, Garcia-Cassani, Bethania, Flavell, Richard A, Kammoun, Hana, Peduto, Lucie, Matthew R. Hepworth, Hung-Wei Cheng, Mattias Svensson, Czarnewski, Paulo, Flavell, Richard, A., Hana Kammoun, Richard A. Flavell, Svensson, Mattias, Huber, Samuel, Cheng, Hung-Wei, Willinger, Tim, Hepworth, Matthew, Sara M. Parigi, Bethania García-Cassani, Parigi, Sara M, Veiga-Fernandes, Henrique, Lucie Peduto, Natalie Sleiers, Tim Willinger, Elke Scandella, Sleiers, Natalie, Das, Srustidhar, Burkhard Ludewig, Johanna Emgård, Elza Evren, Felipe Melo-Gonzalez, João P. Pereira, Villablanca, Eduardo, Evren, Elza, Julie Chesné, Pereira, Joao P, Chesne, Julie, Srustidhar Das, Pereira, Joao   +53 more
core   +1 more source

Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

, 1999
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7α-hydroxylase expression.
Fits, L. van der, Twisk, J., Mager, W.H., Wit, E.C.M. de, Post, S.M., Princen, H.M.G., Hoekman, M.F.M.   +6 more
core  

hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation

, 2001
The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern its activity.
Hedlund, Eva, Lathe, Richard, Dobbie, Lorraine, Allan, Adrian, Stapleton, Genevieve, Seckl, Jonathan R., Gustafsson, Jan-Åke, Dott, Karin, Martin, Cecile, Gauldie, Stephan, Rose, Ken, Wang, Ling   +11 more
core   +1 more source