Results 41 to 50 of about 44,914 (140)

Datasets generated and/or analysed for paper entitled: "Oxysterol 7α,25OHC synthesising enzymes, CH25H and CYP7B1, are upregulated in the blood-brain barrier during inflammation"

, 2022
Images collected and datasets generated and/or analyzed for a paper entitled: "Oxysterol 7α,25OHC synthesising enzymes, CH25H and CYP7B1, are upregulated in the blood-brain barrier during ...
Aleksandra Rutkowska
core   +1 more source

Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase in rat hepatocytes

, 1997
Consumption of boiled coffee raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase.
Wit, E.C.M. de, Post, S.M., Princen, H.M.G.   +2 more
core   +2 more sources

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis [PDF]

, 1996
Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis. Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals.
Liang, Kai Hui, Oveisi, Fariba, Vaziri, Nosratola D.   +2 more
core   +1 more source

Hormetic Effects of 7‐Ketocholesterol in Preventing Ferroptosis in Hepatocytes

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Background and Aims Ferroptosis, a form of cell death marked by iron dysregulation and lipid peroxidation, has been implicated in liver and neurodegenerative diseases. 7‐ketocholesterol (7KC), a cholesterol oxidation product, induces oxidative stress and inflammation at high concentrations.
Sarit Anavi, Nicole Giltman, Haim Zeigerman, Zecharia Madar, Oren Tirosh, Liang-Jun Yan   +5 more
wiley   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Regulation of rat liver microsomal cholesterol 7α-hydroxylase by MgATP: Effect of pH

, 1983
Cholesterol 7α-hydroxylase when assayed under conditions that favour phosphorylation can be activated or inactivated by MgATP, depending on ATP concentration and the pH of the incubation medium. Maximum stimulation of 7α-hydroxylase was obtained with 0.5
Praga Pillay S., Kwok C.T., Hardie I.R.
core   +1 more source

Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription

, 1995
Evidence from in vivo studies indicates that the bile acid pool and bile acid excretion are increased in humans with diabetes mellitus and in experimental diabetic animals, and that both parameters return to normal levels after administration of insulin.
Twisk, J., Mager, W.H., Meijer, P., Princen, H.M.G., Hoekman, M.F.M., Lehmann, E.M.   +5 more
core   +2 more sources

Revisiting Cholesterol‐Lowering Nutraceuticals and Functional Foods: Mechanistic Insights Into Cholesterol Homeostasis and Gut Microbiota

Food Chemistry International, Volume 1, Issue 3, Page 265-293, September 2025.
Mechanistic Insights into Cholesterol Homeostasis and Gut Microbiota. ABSTRACT The gut microbiota acts as a crucial intermediary between diets and human health. The accumulating evidence suggests that gut microbiota may play a significant role in cholesterol metabolism.
Xiaoxuan Zhang, Huafang Ding, Wensen He, Shouhe Huang, Lin Lei   +4 more
wiley   +1 more source

HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia [PDF]

, 2003
HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.BackgroundHereditary analbuminemia is associated with hypercholesterolemia, which has been shown to be primarily caused by increased ...
Liang, Kaihui, Vaziri, Nosratola D.
core   +1 more source