Results 31 to 40 of about 44,914 (140)

On the substrate specificity of human CYP27A1

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

THE LEVEL OF 27-HYDROXYCHOLESTEROL AND OXYSTEROL 7 α-HYDROXYLASE (CYP7B1) IN TISSUES OF WOMEN WITH BREAST TUMORS

The Iraqi Journal of Medical Sciences, 2018
Background:In Iraq, breast cancer is the commonest type of malignancy in females. The disease is a genetically and clinically heterogeneous.
Zahraa Mohammed, Hassan AL-Saeed, Anees Nile   +2 more
doaj   +1 more source

IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production

Frontiers in Immunology, 2017
The behaviors of lymphocytes, including CD4+ T helper cells, are controlled on many levels by internal metabolic properties. Lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids ...
Solenne Vigne, Fanny Chalmin, Donovan Duc, Aurélie S. Clottu, Lionel Apetoh, Jean-Marc A. Lobaccaro, Isabelle Christen, Juan Zhang, Caroline Pot, Caroline Pot   +9 more
doaj   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism [PDF]

, 2020
Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Crosby, Andrew H, Dias, Irundika Hk., Baple, Emma L., Baple, Emma L, Crosby, Andrew H., Borah, Khushboo, Rickman, Olivia J, Griffiths, Helen R, Rickman, Olivia J., Ampong, Isaac, Voutsina, Nikol, Gao, Dan, Griffiths, Helen R., Dias, Irundika HK   +13 more
core   +2 more sources

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, Volume 13, Issue 48, 28 August 2026.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A)

, 2000
A 7 alpha-hydroxylation is necessary for conversion of both cholesterol and 27-hydroxycholesterol into bile acids. According to current theories, cholesterol 7 alpha-hydroxylase (CYP7A) is responsible for the former and oxysterol 7 alpha-hydroxylase ...
Andersson, U, Norlin, M, Wikvall, Kjell,, Björkhem, Ingemar, Norlin, Maria,, Andersson, Ulla, Björkhem, I,, Wikvall, K   +7 more
core   +1 more source

The plasma level of 7α-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7α-hydroxylase in man [PDF]

, 1991
Circulating levels of 7α-hydroxy-4-cholesten-3-one have been compared with activities of the rate-limiting enzyme in bile acid synthesis, microsomal cholesterol 7α-hydroxylase, measured in liver biopsies obtained from patients undergoing surgery for ...
Axelson, Magnus, Kurt Einarsson, REIHNER, E, Ingemar Björkhem, AXELSON, M, EINARSSON, K, Björkhem, Ingemar, Eva Reihnér, Magnus Axelson, Reihnér, Eva, BJORKHEM, I, Einarsson, Kurt   +11 more
core   +1 more source