Results 21 to 30 of about 44,914 (140)

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism

Journal of Pharmacy and Bioallied Sciences, 2011
It is well known that drug disposition and response are greatly determined by the activities of drug metabolizing enzymes, which are polymorphic.
Vera Dias, V Ribeiro
doaj   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source

Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus [PDF]

, 1995
We investigated the lobular localization and molecular level of expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase, two key enzymes in bile acid synthesis, in isolated periportal and pericentral hepatocytes and by in situ hybridization of
Moorman, A.F.M., Twisk, J.W.R., M F Hoekman, Gebhardt, R., A F Moorman, H M Princen, Sheja, L., Twisk, J., W H Mager, J Twisk, Scheja, L., Moorman, A. F., Boer, P.A.J. de, L Scheja, de Boer, P. A., Princen, H. M., R Gebhardt, Mager, W. H., Mager, W.H., Hoekman, M. F., Princen, H.M.G., de Boer, P.A.J., Hoekman, M.F.M., P A de Boer, Gebhart, R.   +24 more
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Differences in mechanisms of modulation between rat liver cholesterol 7α-hydroxylase and HMG-CoA reductase [PDF]

, 1985
The effects of microsomal HMG-CoA reductase kinase, cytosolic phosphoprotein phosphatase and cytosolic, thiol-dependent cholesterol 7α-hydroxylase stimulatory protein on purified cholesterol 7α-hydroxylase and HMG-CoA reductase from rat liver were ...
Bodil Lidström-Olsson, Lidström-Olsson, Bodil   +1 more
core   +1 more source

The acidic pathway of bile acid synthesis: Not just an alternative pathway

Liver Research, 2019
Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased.
William M. Pandak, Genta Kakiyama
doaj   +1 more source

Influence of ursodeoxycholic acid on blood glucose, insulin and GLP-1 in rats with liver fibrosis induced by bile duct ligation

Diabetology & Metabolic Syndrome, 2023
Background The prevalence of impaired glucose tolerance and diabetes is much higher in people with cirrhosis than that in the general population.
Xiu-Ping Bai, Wen-Jin Du, Hua-Bing Xing, Guo-Hua Yang, Rui Bai   +4 more
doaj   +1 more source

Molecular cloning of cDNA for cholesterol 7α-hydroxylase from rat liver microsomes Nucleotide sequence and expression [PDF]

, 1989
A complete cDNA clone encoding cholesterol 7α-hydroxylase was isolated from a rat liver cDNA library by the use of specific antibodies to the enzyme. The isolated cDNA clone was 3.6 kbp long and contained a 1509-bp open reading frame encoding 503 amino ...
Okuda, Kyuichiro, Masazumi Nishimoto, Kyuichiro Okuda, Noshiro, Mitsuhide, Mitsuhide Noshiro, Nishimoto, Masazumi, Ken-ichirou Morohashi, Morohashi, Ken-ichirou   +7 more
core   +1 more source

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α

Journal of Lipid Research, 2006
Hepatocyte nuclear factor 4α (HNF4α) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4α (HNF4αΔL) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4α-floxed (HNF4αF/F ...
Yusuke Inoue, Ai-Ming Yu, Sun Hee Yim, Xiaochao Ma, Kristopher W. Krausz, Junko Inoue, Charlie C. Xiang, Michael J. Brownstein, Gösta Eggertsen, Ingemar Björkhem, Frank J. Gonzalez   +10 more
doaj   +1 more source

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), a primary cause of liver disease, leads to complications such as fibrosis, cirrhosis, and carcinoma, but the pathophysiology of NASH is incompletely understood. Epstein Barr virus induced G protein coupled receptor 2
Spalinger, MR, Moncsek, A, Rogler, Gerhard, Heran, T, Griffiths, William J, Peter, Alain, Spalinger, Marianne R, Maggio, Ewerton M, Bueter, Marco; https://orcid.org/, Peter, A, Frey-Wagner, Isabelle, Maggio, EM, Schmitt, J, Maggio, Ewerton M., Mertens, Joachim, Bueter, Marco, Schmitt, Johannes, Misselwitz, B, Geier, Andreas, Sailer, Andreas W., Moncsek, Anja, Scharl, M, Wiest, R, Misselwitz, Benjamin, Wang, Y, Sailer, Andreas W, Raselli, T, Wyss, A, Schreiner, P, Mertens, J, Geier , A, Raselli, Tina, Griffiths, WJ, Hearn, Tom, Frey-Wagner, I, William Griffiths, Wyss, Annika, Scharl, Michael, Bueter, M, Atrott, Kirstin, Wang, Yuqin, Griffiths, William J., Atrott, K, Schreiner, Philipp, Rogler, G, Sailer, Andreas, Spalinger, Marianne R.   +46 more
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Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source