Results 1 to 10 of about 44,914 (140)
Successful treatment of infantile oxysterol 7α-hydroxylase deficiency with oral chenodeoxycholic acid [PDF]
BMC Gastroenterology, 2021 Background Deficiency of oxysterol 7α-hydroxylase, encoded by CYP7B1, is associated with fatal infantile progressive intrahepatic cholestasis and hereditary spastic paraplegia type 5.
Yun-Ping Tang +5 more
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GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell
Molecules, 2022 7α,25-dihydroxycholesterol (7α,25-DHC) is an oxysterol synthesized from 25-hydroxycholesterol by cytochrome P450 family 7 subfamily B member 1 (CYP7B1) and is a monooxygenase (oxysterol-7α-hydroxylase) expressed under inflammatory conditions in various ...
Jae-Sung Kim +11 more
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Cells, 2021 Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD).
Schwinge D +2 more
exaly +3 more sources
Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1
Journal of Lipid Research, 1999 Oxysterol 7α-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism.
Zhengliang Wu +3 more
exaly +3 more sources
Pediatrics and Neonatology, 2020 Background: Inborn errors of bile acid metabolism (IEBAM) cause rare but treatable genetic disorders that can present as neonatal cholestasis or neurological diseases.
Ju-Yin Chen +13 more
doaj +2 more sources
Journal of Lipid Research, 2020 NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from benign
Rebecca Martin +2 more
exaly +3 more sources
Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression [PDF]
Journal of Lipid ResearchEffect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD
Genta Kakiyama +13 more
doaj +2 more sources
Journal of Medical Case Reports, 2022 Background Congenital bile acid synthesis disorder type 3 caused by oxysterol 7α-hydroxylase deficiency is an extremely rare genetic liver disease. As it may cause rapid progression to end-stage liver disease, a high cautiousness in diagnosis and early ...
Weiqian Mo +7 more
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Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination
Frontiers in Immunology, 2021 Cholesterol is essential for building and maintaining cell membranes and is critical for several steps in the replication cycle of viruses, especially for enveloped viruses. In mammalian cells virus infections lead to the accumulation of the oxysterol 25-
Mikolaj Adamek +19 more
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PLoS ONE, 2023 Macrophage inhibitory cytokine 1 (MIC-1), which is overproduced in various human cancers and associated with cachexia, acts on the hypothalamus to suppress appetite and reduce body weight.
Min Hee Kim +5 more
doaj +1 more source