Results 101 to 110 of about 14,988,203 (289)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Efficient generation of inflow conditions for large-eddy simulation of street-scale flows

open access: yes, 2008
Using a numerical weather forecasting code to provide the dynamic largescale inlet boundary conditions for the computation of small-scale urban canopy flows requires a continuous specification of appropriate inlet turbulence.
Xie, Zheng-Tong, Castro, Ian P.
core   +1 more source

Numerical simulation of bubble generation in a T-junction [PDF]

open access: yes, 2012
We present a numerical study of the formation of mini-bubbles in a 2D T-junction by means of the fluid dynamics numerical code JADIM. Numerical simulations were carried out for different flow conditions, giving rise to results on the behavior of bubble ...
S. Arias   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The role of temperature on P-induced crystal-fluid interaction : a study on LAU and HEU topologies

open access: yes, 2023
Natural zeolites can be found in soil, oceanic basalts as well as sediments and diagenetic environments. Their peculiar reversible hydration property (i.e., the ability to adsorb and release H2O molecules) and the ability to overhydrate under pressure ...
G. D. Gatta   +3 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nonexistence results for a time-fractional biharmonic diffusion equation

open access: yesBoundary Value Problems
We consider weak solutions of the nonlinear time-fractional biharmonic diffusion equation ∂ t α u + ∂ t β u + u x x x x = h ( t , x ) | u | p $\partial _{t}^{\alpha }u+\partial _{t}^{\beta }u+u_{xxxx}=h(t,x)|u|^{p}$ in ( 0 , ∞ ) × ( 0 , 1 ) $(0,\infty ...
Mohamed Jleli, Bessem Samet
doaj   +1 more source

Oscillation in neutral equations with an ?integrally small? coefficient

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1994
Consider the neutral delay differential equationddt[x(t)-P(t)x(t-t)]+Q(t)x(t-d)=0,???t=t0(*)Where P, Q?C([t0,8],R+), t?(0,8) and d?R+. We obtain several sufficient conditions for the oscillation of all solutions of Eq. (*) without the restriction ?t08Q(s)
J. S. Yu, Ming-Po Chen
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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