Co-crystals have garnered increasing interest in recent years as a beneficial approach to improving the solubility of poorly water soluble active pharmaceutical ingredients (APIs). However, their preparation is a challenge that requires a simple approach
Patrycja Garbacz, Marek Wesolowski
doaj +1 more source
How Activated Carboxylic Acids Can Drive Dissipative Systems
This concept aims to describe the dissipative chemical systems driven by activated carboxylic acids (ACAs), identifying three different types: systems under dissipative conditions (Type 1), energy ratchets (Type 2), and non‐equilibrium steady states (NESS) systems (Type 3).
Matteo Valentini+2 more
wiley +1 more source
Reduction of blood serum cholesterol [PDF]
By feeding a human subject as the sole source of sustenance a defined diet wherein the carbohydrate consists substantially entirely of glucose, maltose or a polysaccharide of glucose, the blood serum cholesterol level of the human subject is ...
Winitz, M.
core +1 more source
New patents on topical anesthetics. [PDF]
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano+6 more
core +1 more source
Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
Abstract BACKGROUND C1‐gases like CO and CO2, significant contributors to climate change, offer the potential for sustainable bioconversion into valuable products. The study explored mixotrophic fermentation using C1‐gases in fed‐batch mode to improve the production of target compounds, focusing on Clostridium aceticum and Clostridium carboxidivorans ...
Marina Fernández‐Delgado+5 more
wiley +1 more source
Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis [PDF]
Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear ...
Dario C. Ramirez+2 more
core +2 more sources
New Cocrystals of Ligustrazine: Enhancing Hygroscopicity and Stability
Ligustrazine (TMP) is the main active ingredient extracted from Rhizoma Chuanxiong, which is used in the treatment of cardiovascular and cerebrovascular diseases, with the drawback of being unstable and readily sublimated.
Yifei Xie+8 more
doaj +1 more source
Comparison of Various Easy-to-Use Procedures for Extraction of Phenols from Apricot Fruits
Phenols are broadly distributed in the plant kingdom and are the most abundant secondary metabolites of plants. Plant polyphenols have drawn increasing attention due to their potential antioxidant properties and their marked effects in the prevention of ...
Vojtech Adam+9 more
doaj +1 more source
Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010
In this study, we examined the highly conserved upp gene in bifidobacteria, which encodes uracil phosphoribosyltransferase and plays a role in the pyrimidine salvage pathway. Specifically, we explore its evolutionary trajectory in bifidobacteria, shedding light on its role in microbial competition in the human gut.
Giulia Longhi+11 more
wiley +1 more source
Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. [PDF]
BACKGROUND: Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact.
Alexander, Neal D+16 more
core +5 more sources