Results 191 to 200 of about 507,211 (287)

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome. [PDF]

Int J Mol Sci
Álvarez-Carrasco P, Morales-Villamil F, Maldonado-Bernal C.   +2 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Exploratory Study of Sex Differences in P-Glycoprotein Function at the Blood-Brain Barrier. [PDF]

Clin Transl Sci
Salvi de Souza G, Liu W, Mossel P, Somsen JF, Bartels AL, Furini CRG, Lammertsma AA, Tsoumpas C, Luurtsema G.   +8 more
europepmc   +1 more source

Phenylsulfonylfuroxans as Modulators of Multidrug-Resistance-Associated Protein-1 and P-Glycoprotein

, 2010
Roberta Fruttero, Marco Crosetti, Konstantin Chegaev, Stefano Guglielmo, Alberto Gasco, Francesco Berardi, Mauro Niso, Roberto Perrone, Maria Antonietta Panaro, Nicola Antonio Colabufo   +9 more
openalex   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

A multimodal contrastive learning framework for predicting P-glycoprotein substrates and inhibitors. [PDF]

J Pharm Anal
Zhang Y, Wu J, Kang Y, Hou T.
europepmc   +1 more source

Structure–activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport

, 2016
Kenichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu   +4 more
openalex   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

Tracing the substrate translocation mechanism in P-glycoprotein

Theresa Gewering, Deepali Waghray, Kristian Parey, Hendrik Jung, Nghi N.B. Tran, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Gerhard Hummer, Ina L. Urbatsch, Arne Moeller, Qinghai Zhang   +12 more
openalex   +1 more source

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

, 1994
Ellen C. Spoelstra, Hans V. Westerhoff, Herbert M. Pinedo, Henk Dekker, Jan Lankelma   +4 more
openalex   +2 more sources