Results 201 to 210 of about 515,205 (257)

RETRACTION: P-Glycoprotein Exacerbates Brain Injury Following Experimental Cerebral Ischemia by Promoting Proinflammatory Microglia Activation. [PDF]

Oxid Med Cell Longev
Cellular Longevity OMA.
europepmc   +1 more source

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome. [PDF]

Int J Mol Sci
Álvarez-Carrasco P, Morales-Villamil F, Maldonado-Bernal C.   +2 more
europepmc   +1 more source

Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. [PDF]

Comput Struct Biotechnol J
Han SB, Warwicker J, Fan H, Prince SM.
europepmc   +1 more source

Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion. [PDF]

Nat Commun
Cui C, Fang L, Li L, Lai X, Zhang R, Zhang Q, Miao R, Hu G, Zhang M, Sia JEV, Chen J, Chai H, Wu X, Lin Z, Zhang F, Li H, Zheng L, Liu D.   +17 more
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Exploratory Study of Sex Differences in P-Glycoprotein Function at the Blood-Brain Barrier. [PDF]

Clin Transl Sci
Salvi de Souza G, Liu W, Mossel P, Somsen JF, Bartels AL, Furini CRG, Lammertsma AA, Tsoumpas C, Luurtsema G.   +8 more
europepmc   +1 more source

A multimodal contrastive learning framework for predicting P-glycoprotein substrates and inhibitors. [PDF]

J Pharm Anal
Zhang Y, Wu J, Kang Y, Hou T.
europepmc   +1 more source

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The biology of the P-glycoproteins

The Journal of Membrane Biology, 1995
The initial discovery of p-glycoprotein in the plasma membrane of MDR cancer cell lines was followed quickly by the cloning of its gene. Sequence analysis of cloned cDNAs revealed that p-glycoprotein was a member of the ABC family of membrane transporters.
C R, Leveille-Webster, I M, Arias
openaire   +2 more sources

P-glycoprotein homologues

1994
Multidrug resistance (MDR) is defined by the simultaneous acquisition of cellular resistance to a broad range of cytotoxic compounds bearing little or no structural and functional homologies [1–5]. MDR is caused in cultured cells in vitro [6–9] and in tumor cells in vivo [10–12] by the overexpression of P-glycoprotein (Pgp) (reviewed in [13]).
E, Buschman, P, Lepage, P, Gros
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P-Glycoprotein and Multidrug Resistance

New England Journal of Medicine, 1996
Although the phenomenon of simultaneous resistance to multiple cytotoxic drugs (multidrug resistance) in cancer cells has been discussed for more than two decades, and the human and mouse genes encoding an energy-dependent transporter (the multidrug transporter or P-glycoprotein) responsible for multidrug resistance were cloned 10 years ago, there is ...
M M, Gottesman, I, Pastan, S V, Ambudkar
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P-glycoproteins in nematodes

Parasitology Today, 1994
The P-glycoprotein (Pgp), a member of a group of integral membrane proteins that contain the ATP-binding cassette, is widely represented in the animal kingdom. A family of Pgp homologues has recently been described in nematodes. Pgps have been implicated in drug resistance in Plasmodium and in other parasitic protozoa, so the interest of ...
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