Results 221 to 230 of about 507,211 (287)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1-phosphate receptor 1. [PDF]

Fluids Barriers CNS
Nosratabadi F, Endres LM, Schumacher F, Claus H, Kleuser B, Kim BJ, Schubert-Unkmeir A.   +6 more
europepmc   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein. [PDF]

Antioxidants (Basel)
Hu J, Feng J, Bai Y, Yao ZS, Wu XY, Hong XY, Lu GD, Xue K.   +7 more
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

<i>Mapping cardiac drug transport: In vitro</i> assessment of cardiac P-glycoprotein function with [¹⁸F]MC225 by using µ-engineered heart tissues. [PDF]

Eur Heart J Open
Liu W, Dannenberg M, Mossel P, Cai Z, Farinha Antunes I, Sijbesma J, Kwizera C, Cao L, van der Meer A, Passier R, Slart RHJA, Schwach V, Luurtsema G.   +12 more
europepmc   +1 more source

Specifics of drug-drug interactions between rivaroxaban and a P-glycoprotein inhibitor depending on the <i>CYP3A4/A5</i> gene polymorphism in patients aged 80 years and older with non-valvular atrial fibrillation

М. С. Черняева, Irena Konstantinova, E. I. Baranovskaya, О. В. Головина, I. I. Sinitcina, П. О. Бочков, Sh. P. Abdullaev, Н. П. Денисенко, G. A. Sozaeva, К. Б. Мирзаев, N. V. Lomakin, Д. А. Сычев   +11 more
openalex   +2 more sources

Detection of Multidrug Resistance Gene (MDR1) in Bovine, Equine and vian Genomic DNA and Immunohistochemical Detection of P-glycoprotein in Canine Mammary gland Tumors

, 2002
三好 宣彰, 安田 宣紘, 高山 健二, 亀山 和久, 藤木 誠, Kazuhiro Misumi, Akihiro Ohishi, 坂本 紘, 清水 孜   +8 more
openalex   +2 more sources

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Development of heterocyclic derivatives as P-glycoprotein inhibitors against multidrug resistance: pharmacological activities, structure-activity relationship and target (2020-2024). [PDF]

RSC Med Chem
Yang Z, Yang Y, Huang Z, Hua Y, Hassaan MEAE, Wang H.   +5 more
europepmc   +1 more source