Results 71 to 80 of about 19,039,568 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Matrices

, 2017
This file contains the matrices used for the main analyses and matrices used for the analyses in SI appendix ...
Ellie Owen (3294219), Freeman, Robin, Mark Bolton (132313), Browning, Ella, Bolton, Mark, Guilford, Tim, Akiko Shoji (354607), Owen, Ellie, Shoji, Akiko, Robin Freeman (214892), Ella Browning (4922512), Tim Guilford (214890)   +11 more
core   +1 more source

Empirical codon substitution matrix

BMC Bioinformatics, 2005
Background Codon substitution probabilities are used in many types of molecular evolution studies such as determining Ka/Ks ratios, creating ancestral DNA sequences or aligning coding DNA.
Gonnet Gaston H, Cannarozzi Gina M, Schneider Adrian   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Square matrices with the inverse diagonal property

Kuwait Journal of Science
We identify the class of real square invertible matrices A for which the signs of the diagonal entries of A−1 match those of A, and begin their study. We say such matrices have the inverse diagonal property (IDP).
Susana Furtado, Charles R. Johnson, Carlos Marijuán, Miriam Pisonero   +3 more
doaj   +1 more source

Profiling and quantitative evaluation of three Nickel-Coated magnetic matrices for purification of recombinant proteins: lelpful hints for the optimized nanomagnetisable matrix preparation

Journal of Nanobiotechnology, 2011
Background Several materials are available in the market that work on the principle of protein magnetic fishing by their histidine (His) tags. Little information is available on their performance and it is often quoted that greatly improved purification ...
Zarei Saeed, Chamankhah Mahmood, Nejadmoghaddam Mohammad, Zarnani Amir   +3 more
doaj   +1 more source

Convex maps on $\protect \mathbb{R}^n$ and positive definite matrices

Comptes Rendus. Mathématique, 2020
We obtain several convexity statements involving positive definite matrices. In particular, if $A,B,X,Y$ are invertible matrices and $A,B$ are positive, we show that the map \[ (s,t) \mapsto \mathrm{Tr}\,\log \left(X^*A^sX + Y^*B^tY\right) \] is jointly ...
Bourin, Jean-Christophe, Shao, Jingjing
doaj   +1 more source

Linear transformations that map the P-matrices into themselves

Linear Algebra and its Applications, 1986
Les AA. considèrent les trois ensembles suivants de matrices carrées, réelles ou complexes, de taille \(n\times n\); \(P=ensemble\) de matrices \(n\times n\) dont tous les mineurs principaux sont positifs; \(P_ 0=ensemble\) de matrices \(n\times n\) dont tous les mineurs principaux sont non négatifs; \(P^+_ 0=ensemble\) de matrices \(n\times n\) dont l'
Hershkowitz, Daniel, Johnson, Charles R.
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source