Results 91 to 100 of about 28,541,050 (306)

Twin Toughening‐Driven Martensitic Transformation Strategy Synergistic Improvement for Plasticity‐Thermal Shock Resistance of (Hf─Zr─Ti)C Ceramic Coating in Severe Thermal Environments

Advanced Science
The inherent brittleness and insufficient thermal shock resistance of ultra‐high temperature ceramic (UHTC) in severe thermal environments (above 2000 °C) remain significant challenges.
Jiachen Li, Yulei Zhang, Yanqin Fu, Tao Li, Jian Zhang, Deyu Yang, Lingfei Cao, Fanyu Lu, Junhao Zhao, Junshuai Lv, Hejun Li   +10 more
doaj   +1 more source

New accelerated modulus-based iteration method for solving large and sparse linear complementarity problem

Journal of Numerical Analysis and Approximation Theory
For the large and sparse linear complementarity problem, we provide a family of new accelerated modulus-based iteration methods in this article. We provide some sufficient  criteria for the convergence analysis when the  system matrix is a \(P\)-matrix ...
Bharat Kumar, Deepmala, A. K. Das
doaj   +1 more source

Compact matrix operators on a new sequence space related to ℓ p $\ell_{p}$ spaces

Journal of Inequalities and Applications, 2016
In this paper, we derive some identities or estimates for the operator norms and the Hausdorff measures of noncompactness of certain matrix operators on the sequence space ℓ p ( r , s , t ; B ( m ) ) $\ell_{p}(r,s,t;B^{(m)})$ which is related to ℓ p ...
Abdullah Alotaibi, Mohammad Mursaleen, Syed Abdul Mohiuddine   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Matrix metalloproteinases /

, 1998
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity.
Mecham, Robert P., Parks, William C.
core  

Computational Modeling of Single-Cell Migration::The Leading Role of Extracellular Matrix Fibers [PDF]

, 2012
Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as
Ramis-Conde, Ignacio, Chaplain, Mark A. J., Schlueter, Daniela K., Chaplain, Mark A. J.; id_orcid   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The information matrix test with bootstrap-based covariance matrix estimation. [PDF]

We propose an information matrix test in which the covariance matrix of the vector of indicators is estimated using the parametric bootstrap. Monte Carlo results and heuristic arguments show that its small sample performance is comparable with that of ...
Hoorelbeke, Dirk, Dhaene, Geert
core   +2 more sources

The New Hahn Sequence Space via $(p,q)$-Calculus

Communications in Advanced Mathematical Sciences
In this paper, a novel generalized Hahn sequence space, denoted as $h(C(p,q))$, is introduced by utilizing the $(p, q)$-Cesaro matrix. Fundamental properties of this sequence space, such as its completeness and inclusion relations with other well-known ...
Serkan Demiriz, Sezer Erdem, Hacer Bilgin Ellidokuzoğlu   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source