Results 71 to 80 of about 27,019,626 (261)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Matrix metalloproteinases /

, 1998
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity.
Mecham, Robert P., Parks, William C.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Matrix

, 2018
Matrix of 53 dental characters and 13 paromomyid ...
Sergi López-Torres (7061078), Mary Silcox (5461604)   +1 more
core   +1 more source

Matrix-Based Ramanujan-Sums Transforms

, 2022
In this letter, we study the Ramanujan Sums (RS) transform by means of matrix multiplication. The RS are orthogonal in nature and therefore offer excellent energy conservation capability.
Sridhar Krishnan (14025273), Tien D. Bui (14035289), Guangyi Chen (729352)   +2 more
core   +1 more source

Twin Toughening‐Driven Martensitic Transformation Strategy Synergistic Improvement for Plasticity‐Thermal Shock Resistance of (Hf─Zr─Ti)C Ceramic Coating in Severe Thermal Environments

Advanced Science
The inherent brittleness and insufficient thermal shock resistance of ultra‐high temperature ceramic (UHTC) in severe thermal environments (above 2000 °C) remain significant challenges.
Jiachen Li, Yulei Zhang, Yanqin Fu, Tao Li, Jian Zhang, Deyu Yang, Lingfei Cao, Fanyu Lu, Junhao Zhao, Junshuai Lv, Hejun Li   +10 more
doaj   +1 more source

New accelerated modulus-based iteration method for solving large and sparse linear complementarity problem

Journal of Numerical Analysis and Approximation Theory
For the large and sparse linear complementarity problem, we provide a family of new accelerated modulus-based iteration methods in this article. We provide some sufficient  criteria for the convergence analysis when the  system matrix is a \(P\)-matrix ...
Bharat Kumar, Deepmala, A. K. Das
doaj   +1 more source

Compact matrix operators on a new sequence space related to ℓ p $\ell_{p}$ spaces

Journal of Inequalities and Applications, 2016
In this paper, we derive some identities or estimates for the operator norms and the Hausdorff measures of noncompactness of certain matrix operators on the sequence space ℓ p ( r , s , t ; B ( m ) ) $\ell_{p}(r,s,t;B^{(m)})$ which is related to ℓ p ...
Abdullah Alotaibi, Mohammad Mursaleen, Syed Abdul Mohiuddine   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source