Results 61 to 70 of about 21,096,303 (314)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

On pseudospectra of matrix polynomials and their boundaries

, 2008
In the first part of this paper (Sections 2-4), the main concern is with the boundary of the pseudospectrum of a matrix polynomial and, particularly, with smoothness properties of the boundary.
Boulton, Lyonell; id_orcid, Lancaster, Peter, Psarrakos, P, Lancaster, P, Psarrakos, Panayiotis, Boulton, L   +5 more
core   +1 more source

MATRIX TRANSFORMATIONS OF c0(p,s), 100(p,s) and l(p,s) INTO Q

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 1997
Necessarv and sufficicnt condi­ , tions haYe been cstablished for an infini te matrix A= (͙k) to transform c0(p,s) , f.00(p,s) and ((p,s) into Q (semipcriodic scqucnces space), \vhere c0(pšs) and e00( p,s) the set of aJJ complex sequenccs X= (xk) such ...
MİKAİL ET, METİN BAŞARIR
doaj   +1 more source

Some generalizations of inequalities for sector matrices

Journal of Inequalities and Applications, 2018
In this paper, we generalize some Schatten p-norm inequalities for accretive-dissipative matrices obtained by Kittaneh and Sakkijha. Moreover, we present some inequalities for sector matrices.
Chaojun Yang, Fangyan Lu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Grewia polysaccharide as a pharmaceutical excipient in matrix tablets [PDF]

, 2011
Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix.
Conway, Barbara R, Barbara R. Conway, Nep, Elijah I., Nep, E.I., Conway, Barbara R., Elijah I. Nep   +5 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Chirality Evolution of Supramolecular Helices by Electron Transfer Assisted Secondary Nucleation

Advanced Science
Chirality evolution is ubiquitous and important in nature, but achieving it in artificial systems is still challenging. Herein, the chirality evolution of supramolecular helices based on l‐phenylalanine derivative (LPF) and naphthylamide derivate (NDIAPY)
Laiben Gao, Xiaoqiu Dou, Chao Xing, Kaikai Yang, Changli Zhao, Chuanliang Feng   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source