Results 61 to 70 of about 28,541,050 (306)

Application of Haddon’s matrix in qualitative research methodology: an experience in burns epidemiology [PDF]

Background: Little has been done to investigate the application of injury specific qualitative research methods in the field of burn injuries. The aim of this study was to use an analytical tool (Haddon’s matrix) through qualitative research methods to ...
عرشی, شهنام, صادقی, همایون, محمدی, رضا, دلجوان, رضا, فولادی, نسرین   +4 more
core   +1 more source

CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands

Molecular Therapy: Methods & Clinical Development, 2020
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need.
Isabelle M.A. Lombaert, Vaishali N. Patel, Christina E. Jones, Derrick C. Villier, Ashley E. Canada, Matthew R. Moore, Elsa Berenstein, Changyu Zheng, Corinne M. Goldsmith, John A. Chorini, Daniel Martin, Lee Zourelias, Mark G. Trombetta, Paul C. Edwards, Kathleen Meyer, Dale Ando, Michael J. Passineau, Matthew P. Hoffman   +17 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

On Generalized p,q-Euler Matrix and Associated Sequence Spaces

Journal of Function Spaces, 2021
In this study, we introduce new BK-spaces bsr,tp,q and b∞r,tp,q derived by the domain of p,q-analogue Br,tp,q of the binomial matrix in the spaces ℓs and ℓ∞, respectively.
Taja Yaying, Bipan Hazarika, Mohammad Mursaleen   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Approximating a similarity matrix by a latent class model: A reappraisal of additive fuzzy clustering [PDF]

, 2009
Let Q be a given n×n square symmetric matrix of nonnegative elements between 0 and 1, similarities. Fuzzy clustering results in fuzzy assignment of individuals to K clusters.
Braak, C.J.F., ter, Kourmpetis, Y.I.A., Kiers, H.A.L., Bink, M.C.A.M.   +3 more
core   +1 more source

On general fixed point method based on matrix splitting for solving linear complementarity problem

Journal of Numerical Analysis and Approximation Theory, 2022
In this article, we introduce a modified fixed point method to process the large and sparse linear complementarity problem (LCP) and formulate an equivalent fixed point equation for the LCP and show the equivalence.
Bharat Kumar, Deepmala, A. K. Das
doaj  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

P-value matrix for the variable ‘treatment time’.

, 2019
Black cells indicate non-significant differences between age groups and significant difference with p = 0.000 are left out. The matrix shows that there are virtually no differences between the consecutive age groups for the considered variables.
Uzay Kaymak (6278192), Bilge Çelik (6278189), Caro Fuchs (6278186), Steffie H. A. Brouns (782597), Harm R. Haak (782601)   +4 more
core   +1 more source