Results 51 to 60 of about 1,682,430 (291)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Advanced ScienceConstructing colloidal particles into designated hierarchies with integrated functionalities offers insights into bottom‐up material fabrication. However, the arbitrary and controllable assembly of individual nanoscale and microscale particles remains ...
Jie Zhao +12 more
doaj +1 more source
Matrix regularization of classical Nambu brackets and super p-branes
Journal of High Energy Physics, 2021 We present an explicit matrix algebra regularization of the algebra of volume-preserving diffeomorphisms of the n-torus. That is, we approximate the corresponding classical Nambu brackets using sl N n 2 ℂ $$ \mathfrak{sl}\left({N}^{\left\lceil \frac{n}{2}
Meer Ashwinkumar +2 more
doaj +1 more source
The Tracy--Widom limit for the largest eigenvalues of singular complex Wishart matrices
, 2008 This paper extends the work of El Karoui [Ann. Probab. 35 (2007) 663--714] which finds the Tracy--Widom limit for the largest eigenvalue of a nonsingular $p$-dimensional complex Wishart matrix $W_{\mathbb{C}}(\Omega_p,n)$ to the case of several of the ...
Onatski, Alexei
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
On Generalized p,q-Euler Matrix and Associated Sequence Spaces
Journal of Function Spaces, 2021 In this study, we introduce new BK-spaces bsr,tp,q and b∞r,tp,q derived by the domain of p,q-analogue Br,tp,q of the binomial matrix in the spaces ℓs and ℓ∞, respectively.
Taja Yaying +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
P- 80 DIFFERENTIAL EXPRESSION OF MATRIX METALLOPROTEINASE 7 IN CHRONIC LIVER DISEASES
Annals of Hepatology, 2023 Introduction and Objectives: We recently published that in the serum of patients with chronic Hepatitis C, there are high concentrations of inactive Matrix Metalloproteinases (MMP). However, the MMP has not been studied in other liver diseases.
Daniel Montes de Oca-Angeles +13 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
On general fixed point method based on matrix splitting for solving linear complementarity problem
Journal of Numerical Analysis and Approximation Theory, 2022 In this article, we introduce a modified fixed point method to process the large and sparse linear complementarity problem (LCP) and formulate an equivalent fixed point equation for the LCP and show the equivalence.
Bharat Kumar, Deepmala, A. K. Das
doaj