Results 71 to 80 of about 3,946,788 (277)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Dual Frobenius manifolds of minimal gravity on disk

open access: yesJournal of High Energy Physics, 2018
Liouville field theory approach to 2-dimensional gravity possesses the duality (b ↔ b −1). The matrix counterpart of minimal gravity ℳ(q, p) (q < p co-prime) is effectively described on A q−1 Frobenius manifold, which may exhibit a similar duality p ↔ q,
Aditya Bawane   +2 more
doaj   +1 more source

Arithmetic theory of q-difference equations. The q-analogue of Grothendieck-Katz's conjecture on p-curvatures

open access: yes, 2002
Grothendieck's conjecture on p-curvatures predicts that an arithmetic differential equation has a full set of algebraic solutions if and only if its reduction in positive characteristic has a full set of rational solutions for almost all finite places ...
Di Vizio, Lucia
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Steklov problems for the p−Laplace operator involving Lq-norm

open access: yesMoroccan Journal of Pure and Applied Analysis, 2022
In this paper, we are concerned with the study of the spectrum for the nonlinear Steklov problem of the form {Δpu=|u|p-2uin Ω,|∇u|p-2∂u∂v=λ‖u‖q,∂Ωp-q|u|q-2uon ∂Ω,\left\{ {\matrix{{{\Delta _p}u = {{\left| u \right|}^{p - 2}}u} \hfill & {{\rm{in}}\,\Omega ,
Alaoui My Driss Morchid   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A definable (p,q)-theorem for NIP theories

open access: yesAdvances in Mathematics
Added section 4.1 about VC ...
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Noncritical String Field Theory for 2d Quantum Gravity Coupled to (p, q)-Conformal Fields [PDF]

open access: yesInternational Journal of Modern Physics A, 1997
We propose a noncritical string field theory for 2d quantum gravity coupled to (p, q) conformal fields. The Hamiltonian is described by the generators of the Wp algebra, and the Schwinger–Dyson equation is equivalent to a vacuum condition imposed on the generators of Wp algebra.
Ambjørn, Jan, Watabiki, Y.
openaire   +3 more sources

About the Dedekind psi function in Pauli graphs [PDF]

open access: yes, 2010
We study the commutation structure within the Pauli groups built on all decompositions of a given Hilbert space dimension $q$, containing a square, into its factors.
Planat, Michel R. P.
core   +2 more sources

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