Results 81 to 90 of about 3,941,965 (334)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Gradient $L^q$ theory for a class of non-diagonal nonlinear elliptic systems
, 2017 We consider a class of nonlinear non-diagonal elliptic systems with $p$-growth and establish the $L^q$-integrability for all $q\in [p,p+2]$ of any weak solution provided the corresponding right hand side belongs to the corresponding Lebesgue space and ...
Bulíček, Miroslav +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Steklov problems for the p−Laplace operator involving Lq-norm
Moroccan Journal of Pure and Applied Analysis, 2022 In this paper, we are concerned with the study of the spectrum for the nonlinear Steklov problem of the form {Δpu=|u|p-2uin Ω,|∇u|p-2∂u∂v=λ‖u‖q,∂Ωp-q|u|q-2uon ∂Ω,\left\{ {\matrix{{{\Delta _p}u = {{\left| u \right|}^{p - 2}}u} \hfill & {{\rm{in}}\,\Omega ,
Alaoui My Driss Morchid +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A definable (p,q)-theorem for NIP theories
Advances in MathematicsAdded section 4.1 about VC ...
openaire +2 more sources
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Two Types of Solutions to a Class of (p,q)-Laplacian Systems with Critical Sobolev Exponents in RN
Advances in Mathematical Physics, 2018 We focus on the following elliptic system with critical Sobolev exponents: -div∇up-2∇u+m(x)up-2u=λup⁎-2u+(1/η)Gu(u,v), x∈RN; -div∇vq-2∇v+n(x)vq-2v=μvq⁎-2v+(1/η)Gv(u,v), x∈RN; u(x)>0,v(x)>0, x∈RN, where μ,λ>0 ...
Jing Li, Caisheng Chen
doaj +1 more source
Noncritical String Field Theory for 2d Quantum Gravity Coupled to (p, q)-Conformal Fields [PDF]
International Journal of Modern Physics A, 1997 We propose a noncritical string field theory for 2d quantum gravity coupled to (p, q) conformal fields. The Hamiltonian is described by the generators of the Wp algebra, and the Schwinger–Dyson equation is equivalent to a vacuum condition imposed on the generators of Wp algebra.
Ambjørn, Jan, Watabiki, Y.
openaire +3 more sources
Notes on the algebraic curves in (p,q) minimal string theory
, 2006 Loop amplitudes in (p,q) minimal string theory are studied in terms of the continuum string field theory based on the free fermion realization of the KP hierarchy.
A. Klemm +52 more
core +1 more source