Results 71 to 80 of about 18,638,167 (297)

Plasma substance P and soluble P-selectin as biomarkers of β-thalassemia induced hypercoagulability

Alexandria Journal of Medicine, 2014
Background: Hypercoagulability in thalassemia especially in thalassemia major has emerged as a complication of the disease. There is evidence of increased platelet aggregation and increased proportion of platelets expressing P-selectin in thalassemia.
Samia A. Ebeid, Nadia A. Sadek, Sanaa A. El-Benhawy, Gihan N. Mahmoud   +3 more
doaj   +1 more source

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

Frontiers in Medicine, 2020
Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory.
Hiten D. Mistry, Melissa V. Hott Ogalde, Fiona Broughton Pipkin, Geneviève Escher, Geneviève Escher, Lesia O. Kurlak   +5 more
doaj   +1 more source

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]

PLoS ONE, 2013
Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang, Ning Jiang, Veronika I Zarnitsyna, Arkadiusz G Klopocki, Rodger P McEver, Cheng Zhu   +5 more
doaj   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis

Reumatismo, 2011
Objective: P-selectin is an adhesion molecule expressed by activated endothelial cells and platelets favouring the leukocyte adherence to microvascular endothelium.
G. Valesini, D. Celestino, M. Di Franco, M. Bombardieri, V. Riccieri, A. Spadaro, R. Scrivo   +6 more
doaj   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass [PDF]

, 1999
Objectives: The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. Background: Cardiopulmonary bypass (CPB) leads to systemic inflammation.
Becker, Bernhard F., Hartl, Heinz, Hähnel, Christoph, Massoudy, Parwis, Meisner, Hans, Zahler, Stefan   +5 more
core   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude

Frontiers in Physiology, 2022
Reduced oxygen tensions experienced at high altitudes are thought to predispose to thrombosis, yet there are few studies linking hypoxia, platelet activation, and thrombosis.
Helena A. Turton, Josephine Pickworth, Gordon G. Paterson, Gordon G. Paterson, Allan Lawrie, J. Kenneth Baillie, J. Kenneth Baillie, A. A. Roger Thompson, A. A. Roger Thompson, A. A. Roger Thompson   +9 more
doaj   +1 more source

Better Nanoparticle Targeting with P-Selectin [PDF]

Cancer Discovery, 2016
Abstract A study in mice indicates that the adhesion molecule P-selectin, which is expressed on the endothelium during inflammation, may serve as a target for the delivery of drug-filled nanoparticles to tumors. Antitumor efficacy was achieved in several mouse models of cancer, and the researchers successfully used this approach even ...
openaire   +2 more sources